Manuscript accepted in CELL-REPORTS-D-16-01647R3.
Section Chief: Anand Swaroop, Ph.D. The primary goal of our research is to develop novel therapies for retinal and macular degeneration by delineating cellular pathways and regulatory networks underlying photoreceptor development, aging, and disease. In addition to gene therapy, we are developing stem cell- based approaches for drug discovery and photoreceptor replacement. We seek to understand how photoreceptors originate from stem cells and form synaptic circuits to initiate complex visual process, and how their function is compromised during aging and in disease. We collaborate with scientists all over the world to identify genetic variants/mutations that cause or modify clinical phenotypes in patients with retinitis pigmentosa, cone dystrophies, Leber congenital amaurosis, or age-related macular degeneration.
Section Chief: Tiansen Li, Ph.D.
Unit Chief: Tudor Constantin Badea, M.D, Ph.D. We are using molecular genetic approaches to study the development of neuronal cell types, with a particular focus on neuronal arbor formation in retinal neurons.