268 items

Nano-Sized Solution for Efficient and Versatile CRISPR Gene Editing

September 17, 2019

CRISPR gene-editing technology holds tremendous promise for treating or curing a wide range of devastating disorders, including vision loss.

Two commonly used uveitis drugs perform similarly in NIH-funded clinical trial

September 10, 2019

Methotrexate and the more expensive mycophenolate mofetil performed similarly in a head-to-head clinical trial that compared the two drugs for treating noninfectious uveitis, an eye disease that accounts for up to 15% of blindness in the U. S.

Success of gene therapy for a form of inherited blindness depends on timing

September 9, 2019

Using a canine model of the vision disorder Leber congenital amaurosis, Penn researchers found that photoreceptor cells continue to deteriorate after treatment if it is given too late.

Innovative technique for labeling and mapping inhibitory neurons reveals diverse tuning profile

September 5, 2019

Researchers at the Max Planck Florida Institute for Neuroscience uncovered a diverse palette of inhibition within layer 2/3 of the visual cortex, suggestive of a more complex functional connectivity that may allow for enhanced flexibility of...

Machine learning increases resolution of eye imaging technology

August 27, 2019

Biomedical engineers at Duke University have devised a method for increasing the resolution of optical coherence tomography (OCT) down to a single micrometer scale in all directions.

Researchers identify key areas of measles virus polymerase to target for antiviral drug development

August 12, 2019

Targeting specific areas of the measles virus polymerase, a protein complex that copies the viral genome, can effectively fight the measles virus and be used as an approach to developing new antiviral drugs to treat the serious infectious disease...

Penn Engineering’s blinking eye-on-a-chip used for disease modeling and drug testing

August 7, 2019

People who spend eight or more hours a day staring at a computer screen may notice their eyes becoming tired or dry, and, if those conditions are severe enough, they may eventually develop dry eye disease (DED).

Eye exam: Can specific types of light prevent or slow myopia?

August 5, 2019

At night Lisa Ostrin’s lab at the University of Houston College of Optometry often looks like the setting of a disco slumber party, a place where a child, aged 7 to 14, accompanied by a guardian, sleeps over and is periodically exposed to blue lights...

Disruption of glucose transport to rods and cones shown to cause vision loss in retinitis pigmentosa

July 30, 2019

Retinitis pigmentosa (RP) is a common hereditary eye disorder that leads to the gradual deterioration of rod cells causing reduced peripheral vision and night vision. Subsequent loss of cone photoreceptors cause the loss of high-resolution daylight...

Report: Dry AMD requires broad, systems biology approach leveraging big data, multiple disciplines

July 26, 2019

A large-scale, collaborative, systems biology approach is needed to expedite the discovery of treatments for dry age-related macular degeneration (AMD) – a leading cause of blindness among people 65 and older for which is there is no treatment...