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Simon John, Ph.D. [NEI Strategic Planning]

Simon John, Ph.D.


Dr. John is an Associate investigator of the Howard Hughes Medical Institute, Staff Scientist at The Jackson Laboratory and a Research Assistant Professor in Ophthalmology at Tufts University School of Medicine.

Dr. John received his B.Sc. (joint honors in Zoology and Genetics from University College Cardiff. His Ph.D. (Biology/Human Genetics) was from McGill University where he worked with Rima Rozen and Charles Scriver studying the molecular and population genetics of phenylketonuria. Dr. John’s postdoctoral training (studying genes contributing to essential hypertension) was with Dr. Oliver Smithies at the University of North Carolina at Chapel Hill.

He joined the Jackson laboratory in 1995, and established a research program that focuses on using the mouse to study glaucoma. Dr. John’s group has developed methodologies and tools for analyzing glaucoma phenotypes in mouse eyes, and continues to develop practical mouse models for genetic and therapeutic experiments to understand and treat glaucoma. His laboratory uses use a combination of molecular, genetic, and physiologic methods to identify genes and pathophysiologic processes that contribute to intraocular pressure (IOP) elevation and pressure-induced neurodegeneration in glaucoma. A current focus is the basic neurobiology of glaucomatous neurodegeneration and the possible role of an axonal self-destruct system.

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