Strategies to Investigate the Pathophysiology of Ganglion Cell and Optic Nerve Degeneration
Airlie Conference Center, Airlie, Virginia
November 12-13, 2002
|Tuesday, November 12, 2002|
|* Check-in prior to 12 noon|
|12 noon - 1:00 p.m.||Lunch|
|1:00 p.m. - 2:15 p.m.||Current Hypotheses of Glaucoma Pathophysiology|
|1:00 p.m. - 1:25 p.m.||Donald Zack, M.D., Ph.D., Johns Hopkins
What is glaucoma?
What is the role of intraocular pressure in the etiology of glaucoma?
|1:25 p.m. - 1:40 p.m.||Alan M. Laties, M.D., University of Pennsylvania
What is the vascular component of glaucoma?
|1:40 p.m. - 2:00 p.m.||M. Rosario Hernandez, D.D.S., Washington University
What damages the optic nerve head in glaucoma?
|2:00 p.m. - 2:15 p.m.||Discussion|
|2:15 p.m. - 3:10 p.m.||What Can Animal Models Contribute to the Study of Glaucoma?|
|2:15 p.m. - 2:35 p.m.||John C. Morrison, M.D., Oregon
Primate and rat models of ocular hypertension
|2:35 p.m. - 2:55 p.m.||Simon John, Ph.D., Jackson Labs
Mouse models of inherited ON/GC degeneration
|2:55 p.m. - 3:10 p.m.||Discussion|
|3:10 p.m. - 3:30 p.m.||Break|
|3:30 p.m. - 5:00 p.m.||How is the Biology of the Inner Retina Affected in Glaucoma?|
|3:30 p.m. - 3:55 p.m.||Ben A. Barres, M.D., Ph.D., Stanford University
Retinal ganglion cell interactions and survival
|3:55 p.m. - 4:20 p.m.||Carla J. Shatz, Ph.D., Harvard University
Function and retinal development
|4:20 p.m. - 4:45 p.m.||David Copenhagen, Ph.D., UCSF
Glutamate and synaptic transmission
|4:45 p.m. - 5:00 p.m.||Discussion|
|5:00 p.m. - 6:00 p.m.||Are Mechanisms of Chronic Neurodegeneration Relevant to Glaucoma Etiology?|
|5:00 p.m. - 5:25 p.m.||Jeff Rothstein, M.D., Ph.D., Johns Hopkins
Amyotrophic lateral sclerosis
|5:25 p.m. - 5:50 p.m.||Valina L. Dawson, Ph.D., Johns Hopkins
Parkinson’s Disease and Stroke
|5:50 p.m. - 6:00 p.m.||Discussion|
|6:00 p.m. - 7:15 p.m.||Break/Dinner|
|7:15 p.m. - 9:00 p.m.||Degeneration/Regeneration|
|7:15 p.m. - 7:40 p.m.||Eugene M. Johnson, Ph.D., Washington University
Growth factor deprivation and neuronal cell death.
|7:40 p.m. - 8:05 p.m.||Ben A. Barres, M.D., Ph.D., Stanford Medical School
What are the factors that promote RGC survival and axon regeneration?
|8:05 p.m. - 8:30 p.m.||Bruce R. Ransom, M.D., Ph.D., University of Washington
The optic nerve as a model of CNS ischemic damage.
|8:30 p.m. - 9:00 p.m.||Discussion/Plans for Next Day|
|Wednesday, November 13, 2002|
|7:30 a.m. - 8:30 a.m.||Breakfast|
|8:30 a.m. - 8:55 a.m.||What is known about the microenvironment in the optic nerve-head?|
|8:30 a.m. - 8:55 a.m.||Arthur H. Neufeld, Ph.D., Washington University
Role of NO in RGC Degeneration
|9:00 a.m. - 9:40 a.m.||Presentation on topics to be decided based on day one discussions|
|9:40 a.m. - Noon||Discussion Topics|
|9:40 a.m. - 10:10 a.m.||Can we identify key points that trigger the mechanisms of disease?
Leaders: Eugene M. Johnson, Ph.D./Donald Zack, M.D., Ph.D..
|10:10 a.m. - 10:30 a.m.||Break|
|10:30 a.m. - 11:00 a.m.||Can we devise protective strategies for RGC?
Leaders: Valina L. Dawson, Ph.D./Arthur H. Neufeld, Ph.D..
|11:00 a.m. - 11:30 a.m.||What are the key systems and models that can be explored in RGC neuroprotection?
Leaders: Bruce R. Ransom, M.D., Ph.D./M. Rosario Hernandez, D.D.S..
|11:30 a.m. - Noon||Where do we go next?
Leader: Ruben Adler, M.D..
|Noon - 2:00 p.m.||Working lunch and Recommendations for 5 Priority Areas|
|2:30 p.m.||Rides to Dulles Airport to arrive by 3:30 pm for 5 pm flights.|
|2:30 p.m.||Rides to Reagan-National Airport to arrive by 3:45 pm for 5 pm flights.|