Home > Paul A. Sieving, M.D., Ph.D.

Paul A. Sieving, M.D., Ph.D.

Paul A. Sieving, M.D., Ph.D.
Paul A. Sieving, M.D., Ph.D.

National Eye Institute (NEI)
National Institutes of Health (NIH), Bethesda, MD

  • Director of the National Eye Institute


  • Retina
  • Retinitis pigmentosa
  • X-linked retinoschisis
  • Stargardt disease
  • Leber congenital amaurosis

Current Projects

Dr. Sieving’s area of research is human hereditary retinal and macular degenerations. He maintains a clinical research practice for patients with genetic retinal diseases including retinitis pigmentosa, Stargardt macular degeneration, and juvenile X-linked retinoschisis. His laboratory is studying pharmacological and gene-based approaches to slowing degeneration in transgenic and naturally occurring animal models that are similar to human eye disease. He has served as director of the National Eye Institute since 2001.


Dr. Sieving is the author of more than 150 research articles based on his studies, including articles published in the American Journal of Human Genetics, Journal of the American Medical Association, Science, The Journal of Neuroscience, and major ophthalmology journals. He has also published more than twenty book chapters.

Research Highlights

Dr. Sieving is an internationally recognized expert in juvenile X-linked retinoschisis, a blinding disease of the retina. He developed a mouse model of the disease and successfully treated this using gene therapy which restored retinal function. He is currently completing pre-clinical studies in preparation for human X-linked retinoschisis clinical trials. Dr. Sieving’s pioneering laboratory studies of ciliary neurotrophic factor (CNTF), a naturally occurring protein that fosters the survival of neurons, tested the therapeutic potential of this agent in the treatment of retinitis pigmentosa. He served as the principal investigator for the first human clinical trial of CNTF in an eye disease (Proceedings of the National Academy of Sciences). For more information see: “About the Director”.

The National Eye Institute (NEI), part of the National Institutes of Health, leads the federal government’s research on the visual system and eye diseases. NEI supports basic and clinical science programs that result in the development of sight-saving treatments.

National Eye Institute
(301) 496-5248