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Robert B. Nussenblatt, M.D., M.P.H.

Robert B. Nussenblatt, M.D., M.P.H.
Robert B. Nussenblatt, M.D., M.P.H.

National Eye Institute (NEI)
National Institutes of Health (NIH), Bethesda, MD

  • Chief, Laboratory of Immunology
  • Senior Advisor to the Deputy Director of Intramural Research


  • Mechanisms and treatments of ocular inflammation (uveitis)
  • Ocular immunology
  • Ocular complications of AIDS
  • Cytomegalovirus retinitis

Current Projects

Dr. Nussenblatt serves as a world-class ocular immunologist and expert in designing and conducting clinical research studies. His main interest area is defining human immune mechanisms and how they relate to the eye. His broad area of research on uveitis now includes the role of inflammation in causing age-related macular degeneration (AMD). Dr. Nussenblatt is investigating new therapeutic approaches to treating human disease, including oral tolerance and the use of natural products. His work is also focusing on epigenetic changes as a way to explain disease and non-disease in individuals with the same gene sequences.


Dr. Nussenblatt has authored hundreds of peer-reviewed research papers, dozens of book chapters, and several books, including a standard textbook on uveitis. His work has appeared in publications including the New England Journal of Medicine, Proceedings of the National Academy of Sciences, and the Journal of the American Medical Association. Dr. Nussenblatt is also an editor for ophthalmology publications and holds several patents on ophthalmological procedures.

Research Highlights

  • Advanced the understanding of the underlying biological mechanisms of uveitis, including genetic factors and immunological signals that trigger eye inflammation.
  • Tested new treatments for uveitis, including various immunosuppressant drugs and biologic therapies.
  • Member of data and safety monitoring board of the Studies of Ocular Complications of AIDS (SOCA) research group, which identified safe and effective treatments for cytomegalovirus retinitis in people with AIDS.

The National Eye Institute (NEI), part of the National Institutes of Health, leads the federal government’s research on the visual system and eye diseases. NEI supports basic and clinical science programs that result in the development of sight-saving treatments.

National Eye Institute
(301) 496-5248