NEI Audacious Goals Initiative…restoring vision through regeneration of the retina
The Audacious Goals Initiative (AGI) is an effort by the National Eye Institute to push the boundaries of vision science. By facilitating cross-disciplinary research, the AGI is tackling the most devastating and difficult-to-treat eye diseases.
- New AGI funding: Translation-Enabling Models to Evaluate Survival and Integration of Regenerated Neurons in the Visual System. (December 8, 2017)
- National Eye Institute awards prize for ‘Retina in a dish’ competition. (Sept. 28, 2017)
- Researchers unlock regenerative potential of cells in the mouse retina. (July 26, 2017)
- Stem Cells: Regeneration Methods for the Visual System. Hands-on workshop. (Aug. 28-Sept. 1, 2017)
- NEI hosts an AGI town hall forum at ARVO annual meeting. (May 7, 2017)
- Early Clinical Development of Cell Replacement Therapy. Report charts path to new treatments for retinal diseases. (April 2017)
- NEI Audacious Goals Initiative report outlines strategies to replace or reprogram neurons in the retina. (March 27, 2017)
Imaging Projects: Five bold projects will develop new technology to noninvasively image cells of the eye in unprecedented detail.
Discovery-based Projects: Six NEI Audacious Goals Initiative (AGI) projects aim to identify biological factors that affect neural regeneration in the retina.
Mark S. Blumenkranz, M.D., Stanford University, delivered a summary of Audacious Goals Initiative Town Hall held during the 2017 annual meeting of the Association for Research in Vision and Ophthalmology. He presented this summary to the National Advisory Eye Council of the National Eye Institute on October 12, 2017. Read more.
The NEI AGI is catalyzing research that will enable the restoration of vision through regeneration of the retina. The central goal is to replace cells of the retina that have been damaged by disease or injury and to restore their connections to the visual centers of the brain. Through strategic research funding, the NEI is enlisting dynamic scientists and teams who are developing the necessary knowledge and technology to make the goal a reality. Read more about the AGI.
The NEI audacious goal is to regenerate neurons and neural connections in the eye and visual system. The NEI AGI is targeting the photoreceptors and retinal ganglion cells. Photoreceptors—often called rods and cones—are cells in the retina that when stimulated by light generate signals the brain perceives as images. The retinal ganglion cells carry the signals from the photoreceptors to the brain. Read more about the audacious goal.