Symposium: Immunology of Age-Related Macular Degeneration (AMD)

March 6, 2014
Masur Auditorium
National Institutes of Health
Bethesda, Maryland

This symposium will focus on the differences that have recently been discovered in immune system function in patients with AMD and how it relates to aging—differences which may one day open the door to possible new approaches to identify and treat people who are at high risk for AMD.

Watch the video archive of the symposium at

Read the symposium summary.

8:25 AM
Welcome Paul Sieving, M.D., Ph.D., National Eye Institute
Meeting Goals Robert Nussenblatt, M.D., MPH, National Eye Institute

8:35-8:55 AM
I. AMD- Review of the Disease
Emily Chew, M.D., National Eye Institute
The Disorder: Risk Factors in Different Populations and a Simple Classification System

8:55-9:15 AM
Anand Swaroop, Ph.D., National Eye Institute
Genetics of AMD

9:15-9:45 AM
II. Immunology of Aging in Humans (Immunosenescence)
Arne Akbar, Ph.D., University College London, UK

9:45-10:10 AM
Questions I and II

10:10-10:35 AM

10:35-11:55 AM
III. Models for AMD

Current Understanding of Inflammatory Pathways in the Eye

Rachel Caspi, Ph.D., National Eye Institute

Animal Models — 15 min. each

Chi-Chao Chan, M.D., National Eye Institute

Joe Hollyfield, Ph.D., Cleveland Clinic

Jayakrishna Ambati, Ph.D., University of Kentucky

Ignacio Rodriguez, Ph.D., National Eye Institute

Patricia Becerra, Ph.D., National Eye Institute
12:00-12:20 PM
Andrew Dick, Ph.D., University of Bristol and University College London, UK
Kapil Bharti, Ph.D., National Eye Institute
Panel Discussion: Enhancing the Models of AMD

12:20-1:20 PM

IV. Immune Characteristics in AMD
1:20-1:40 PM
Sheldon Miller, Ph.D., National Eye Institute
miR-155 Control of RPE Inflammation and Physiology

1:40-2:00 PM
Baoying Liu, M.D., Ph.D., National Eye Institute
Complement activation, adaptive immunity, and AMD

2:00-2:20 PM
Jae Jin Chae, Ph.D., National Human Genome Research Institute

2:20-2:40 PM
Lai Wei, Ph.D., Zhongshan Ophthalmic Center, Guangzhou, China
Non-genetic Factors in AMD

2:40-3:00 PM
Charles Egwuagu, MPH, Ph.D., National Eye Institute
Regulation of CFH in the Eye

3:00-3:15 PM
Andrew Dick, Ph.D., University of Bristol and University College London, UK

3:15-3:50 PM
Robert Nussenblatt, M.D., MPH
Panel Discussion

3:50-4:15 PM

V. Recent Concepts
CHAIR — Frederick Ferris, M.D., National Eye Institute

4:15-4:35 PM
Alan Bird, M.D., University College London
Lessons from the Beckman Initiative
4:35-4:55 PM
Robert Nussenblatt, M.D., MPH
Can We See a Possible Immune Role?
4:45-5:15 PM Questions

Last Reviewed: 
April 2014