Publications

Original Papers

See Article Depository

  • Kim HF, Hikosaka O. (2015) Parallel basal ganglia circuits for voluntary and automatic behaviour to reach rewards. Brain 2015 May 16. pii: awv134. [Epub ahead of print]
  • Monosov IE, Leopold DA, Hikosaka O. (2015) Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation. J Neurosci 35(19):7443–7459.
  • Yasuda M, Hikosaka O. (2014) Functional territories in primate substantia nigra pars reticulata separately signaling stable and flexible values. J. Neurophysiology, 113: 1681-1696.
  • Kim HF, Ghazizadeh A, Hikosaka O (2014) Separate groups of dopamine neurons innervate caudate head and tail encoding flexible and stable value memories. Front Neuroanat 8:120.
  • Hong S, Hikosaka O. (2014) Pedunculopontine tegmental nucleus neurons provide reward, sensorimotor, and alerting signals to midbrain dopamine neurons. J Neurosci 282: 139-155.
  • Hong S, Hikosaka O. (2013) Diverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey. Front Hum Neurosci. 7:778.
  • Kim HF, Hikosaka O. (2013) Distinct basal ganglia circuits controlling behaviors guided by flexible and stable values. Neuron 79(5):1001-10.
  • Yamamoto S, Kim HF, Hikosaka O. (2013) Reward value-contingent changes of visual responses in the primate caudate tail associated with a visuomotor skill. J. Neurosci. Jul 3;33(27):11227-38.
  • Monosov IE, Hikosaka O. (2013) Selective and graded coding of reward uncertainty by neurons in the primate anterodorsal septal region. Nat Neurosci. Jun;16(6):756-62.
  • Daye PM, Monosov IE, Hikosaka O, Leopold DA, Optican LM. (2013) pyElectrode: an open-source tool using structural MRI for electrode positioning and neuron mapping. J Neurosci Methods Feb 15;213(1):123-31.
  • Tachibana Y, Hikosaka O. (2012) The primate ventral pallidum encodes expected reward value and regulates motor action. Neuron Nov 21;76(4):826-37.
  • Yasuda M, Yamamoto S, Hikosaka O. (2012) Robust representation of stable object values in the oculomotor Basal Ganglia. J Neurosci. Nov 21;32(47):16917-32.
  • Nakahara H, Hikosaka O. (2012) Learning to represent reward structure: A key to adapting to complex environments. Neurosci Res. [Epub ahead of print]
  • Yamamoto S, Monosov IE, Yasuda M, Hikosaka O. (2012) What and where information in the caudate tail guides saccades to visual objects. J Neurosci. 32(32):11005-16.
  • Monosov IE, Hikosaka O. (2012) Regionally distinct processing of rewards and punishments by the primate ventromedial prefrontal cortex. J Neurosci. 32(30):10318-30.
  • Matsumoto M, Hikosaka O. (2011) Electrical stimulation of the primate lateral habenula suppresses saccadic eye movement through a learning mechanism. PLoS One;6(10):e26701. Epub 2011 Oct 24.
  • Bromberg-Martin ES, Hikosaka O (2011) Lateral habenula neurons signal errors in the prediction of reward information. Nat Neurosci.14(9):1209-16. doi: 10.1038/nn.2902. Erratum in: Nat Neurosci. 2011 Dec;14(12):1617.
  • Hong S, Jhou TC, Smith M, Saleem KS, Hikosaka O. (2011) Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates. J Neurosci., 31(32):11457-71.
  • Isoda M, Hikosaka O. (2011) Cortico-basal ganglia mechanisms for overcoming innate, habitual and motivational behaviors. Eur J Neurosci. 33(11):2058-69.
  • Hong S, Hikosaka O. (2011) Dopamine-mediated learning and switching in cortico-striatal circuit explain behavioral changes in reinforcement learning. Front Behav Neurosci. 5:15.
  • Terao Y, Fukuda H, Yugeta A, Hikosaka O, Nomura Y, Segawa M, Hanajima R, Tsuji S, Ugawa Y. (2011) Initiation and inhibitory control of saccades with the progression of Parkinson’s disease - Changes in three major drives converging on the superior colliculus. Neuropsychologia 49(7):1794-806. Epub 2011 Mar 21.
  • Bromberg-Martin ES, Matsumoto M, Nakahara H, Hikosaka O (2010d) Multiple timescales of memory in lateral habenula and dopamine neurons. Neuron 67:499-510.
  • Bromberg-Martin ES, Matsumoto M, Hikosaka O (2010b) Distinct tonic and phasic anticipatory activity in lateral habenula and dopamine neurons. Neuron 67:144-155.
  • Bromberg-Martin ES, Matsumoto M, Hong S, Hikosaka O (2010c) A pallidus-habenula-dopamine pathway signals inferred stimulus values. J Neurophysiol 104:1068-1076.
  • Bromberg-Martin ES, Hikosaka O, Nakamura K (2010a) Coding of task reward value in the dorsal raphe nucleus. J Neurosci 30:6262-6272.
  • Yugeta A, Terao Y, Fukuda H, Hikosaka O, Yokochi F, Okiyama R, Taniguchi M, Takahashi H, Hamada I, Hanajima R, Ugawa Y (2010) Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease. Neurology 74:743-748.
  • Bromberg-Martin ES, Hikosaka O (2009) Midbrain dopamine neurons signal preference for advance information about upcoming rewards. Neuron 63:119-126.
  • Matsumoto M, Hikosaka O (2009) Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature 459:837-841.
  • Matsumoto M, Hikosaka O (2009) Representation of negative motivational value in the primate lateral habenula. Nat Neurosci Jan.12 (1):77-84.
  • Hong S, Hikosaka O (2008) The globus pallidus sends reward-related signals to the lateral habenula. Neuron 60:720-729.
  • Bissmarck F, Nakahara H, Doya K, Hikosaka O (2008) Combining Modalities with Different Latencies for Optimal Motor Control. J Cogn Neurosci 20:1966-1979.
  • Isoda M, Hikosaka O (2008) A neural correlate of motivational conflict in the superior colliculus of the macaque. J Neurophysiol 100:1332-1342.
  • Hikosaka O, Isoda M (2008) Brain mechanisms for switching from automatic to controlled eye movements. Prog Brain Res 171:375-382.
  • Matsumoto M, Hikosaka O (2008) Negative motivational control of saccadic eye movement by the lateral habenula. Prog Brain Res 171:399-402.
  • Isoda M, Hikosaka O (2008) Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement. J Neurosci 28:7209-7218.
  • Nakamura K, Matsumoto M, Hikosaka O (2008) Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus. J Neurosci 28:5331-5343.
  • Ikeda T, Hikosaka O (2007) Positive and negative modulation of motor response in primate superior colliculus by reward expectation. J Neurophysiol 98: 31633170
  • Matsumoto M, Hikosaka O (2007) Lateral habenula as a source of negative reward signals in dopamine neurons. Nature 447:1111-1115.
  • Isoda M, Hikosaka O (2007) Switching from automatic to controlled action by monkey medial frontal cortex. Nat Neurosci 10:240-248.
  • Kobayashi S, Kawagoe R, Takikawa Y, Koizumi M, Sakagami M, Hikosaka O (2007) Functional differences between macaque prefrontal cortex and caudate nucleus during eye movements with and without reward. Exp Brain Res 176:341-355.
  • Ding L, Hikosaka O (2007) Temporal Development of Asymmetric Reward-Induced Bias in Macaques. J Neurophysiol 97:57-61.
  • Nakamura K, Hikosaka O (2006) Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate. J Neurosci 26:12885-12895.
  • Nakahara H, Nakamura K, Hikosaka O (2006) Extended LATER model can account for trial-by-trial variability of both pre- and post-processes. Neural Netw 19:1027-1046.
  • Kobayashi S, Nomoto K, Watanabe M, Hikosaka O, Schultz W, Sakagami M (2006) Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex. Neuron 51:861-870.
  • Watanabe K, Ikeda H, Hikosaka O (2006) Effects of explicit knowledge of workspace rotation in visuomotor sequence learning. Exp Brain Res 174:673-678.
  • Ding L, Hikosaka O (2006) Comparison of reward modulation in the frontal eye field and caudate of the macaque. J Neurosci 26:6695-6703.
  • Nakamura K, Hikosaka O (2006) Role of dopamine in the primate caudate nucleus in reward modulation of saccades. J Neurosci 26:5360-5369.
  • Watanabe K, Hikosaka O (2005) Immediate changes in anticipatory activity of caudate neurons associated with reversal of position-reward contingency. J Neurophysiol 94:1879-1887.
  • Takikawa Y, Kawagoe R, Hikosaka O (2004) A possible role of midbrain dopamine neurons in short- and long-term adaptation of saccades to position-reward mapping. J Neurophysiol 92:2520-2529.
  • Kawagoe R, Takikawa Y, Hikosaka O (2004) Reward-predicting activity of dopamine and caudate neurons - a possible mechanism of motivational control of saccadic eye movement. J Neurophysiol 91:1013-1024.
  • Nakahara H, Itoh H, Kawagoe R, Takikawa Y, Hikosaka O (2004) Dopamine neurons can represent context-dependent prediction error. Neuron 41:269-280.
  • Nomura Y, Fukuda H, Terao Y, Hikosaka O, Segawa M (2003) Abnormalities of voluntary saccades in Gilles de la Tourette’s syndrome: pathophysiological consideration. Brain Dev 25 Suppl 1:S48-54.
  • Watanabe K, Lauwereyns J, Hikosaka O (2003) Neural correlates of rewarded and unrewarded eye movements in the primate caudate nucleus. J Neurosci 23:10052-10057.
  • Ikeda T, Hikosaka O (2003). Reward-dependent gain and bias of visual responses in primate superior colliculus. Neuron 39: 693-700.
  • Sakai K, Kitaguchi K, Hikosaka O (2003) Chunking during human visuomotor sequence learning. Exp Brain Res 152:229-242.
  • Watanabe K, Lauwereyns J, Hikosaka O (2003) Effects of motivational conflicts on visually elicited saccades in monkeys. Exp Brain Res 152:361-367.
  • Itoh H, Nakahara H, Hikosaka O, Kawagoe R, Takikawa Y, Aihara K (2003) Correlation of Primate Caudate Neural Activity and Saccade Parameters in Reward-Oriented Behavior. J Neurophysiol 89:1774-1783.
  • Hikosaka O, Rand MK, Nakamura K, Miyachi S, Kitaguchi K, Sakai K, Lu X, Shimo Y (2002b) Long-term retention of motor skill in macaque monkeys and humans. Exp Brain Res 147:494-504.
  • Miyachi S, Hikosaka O, Lu X (2002) Differential activation of monkey striatal neurons in the early and late stages of procedural learning. Exp Brain Res 146:122-126.
  • Lauwereyns J, Watanabe K, Coe B, Hikosaka O (2002) A neural correlate of response bias in monkey caudate nucleus. Nature 418:413-417.
  • Coe B, Tomihara K, Matsuzawa M, Hikosaka O (2002) Visual and Anticipatory Bias in Three Cortical Eye Fields of the Monkey during an Adaptive Decision-Making Task. J Neurosci 22:5081-5090.
  • Lu X, Matsuzawa M, Hikosaka O (2002) A neural correlate of oculomotor sequences in supplementary eye field. Neuron 34:317-325.
  • Nakahara H, Amari Si S, Hikosaka O (2002) Self-organization in the basal ganglia with modulation of reinforcement signals. Neural Comput 14:819-844.
  • Sato M, Hikosaka O (2002) Role of primate substantia nigra pars reticulata in reward-oriented saccadic eye movement. J Neurosci 22:2363-2373.
  • Kobayashi S, Lauwereyns J, Koizumi M, Sakagami M, Hikosaka O (2002) Influence of reward expectation on visuospatial processing in macaque lateral prefrontal cortex. J Neurophysiol 87:1488-1498.
  • Takikawa Y, Kawagoe R, Hikosaka O (2002a) Reward-dependent spatial selectivity of anticipatory activity in monkey caudate neurons. Journal of Neurophysiology 87:508-515.
  • Lauwereyns J, Takikawa Y, Kawagoe R, Kobayashi S, Koizumi M, Coe B, Sakagami M, Hikosaka O (2002) Feature-based anticipation of cues that predict reward in monkey caudate nucleus. Neuron 33:463-473.
  • Takikawa Y, Kawagoe R, Itoh H, Nakahara H, Hikosaka O (2002b) Modulation of saccadic eye movements by predicted reward outcome. Experimental Brain Research 142:284-291.
  • Nakahara H, Doya K, Hikosaka O (2001) Parallel cortico-bsal ganglia mechanisms for acquisition and execution of visuomotor seqeunces - A computational approach. Journal of Cognitive Neuroscience 13: 1-22.
  • Sakagami M, Tsutsui K-I, Lauwereyns J, Koizumi M, Kobayashi S, Hikosaka O (2001) A code for behavioral inhibition on the basis of color, but not motion, in ventrolateral prefrontal cortex of macaque monkey. J Neurosci 21: 4801-4808
  • Lauwereyns J, Sakagami M, Tsutsui K-I, Kobayashi S, Koizumi M, Hikosaka O (2001) Responses to task-irrelevant visual features by primate prefrontal neurons. J Neurophysiol 86: 2001-2010.
  • Shimo Y, Hikosaka O (2001) Role of tonically active neurons in primate caudate in reward-oriented saccadic eye movement. J Neurosci 21: 7804-7814.
  • Lauwereyns J, Koizumi M, Sakagami M, Hikosaka O, Kobayashi S, Tsutsui K (2000) Interference from irrelevant features on visual discrimination by macaques (Macaca fuscata) : a behavioral analogue of human stroop effect. Journal of Experimental Psychology: Animal Behavior Processes 26: 352-357.
  • Rand MK, Hikosaka O, Miyachi S, Lu X, Nakamura K, Kitaguchi K, Shimo Y (2000) Characteristics of sequential movements during early learning period in monkeys. Exp Brain Res 131: 293-304.
  • Sakai K, Hikosaka O, Takino R, Miyauchi S, Nielsen M, Tamada T (2000) What and when: parallel and convergent processing in motor control. J Neurosci 20: 2691-2700.
  • Sakai K, Hikosaka O, Miyauchi S, Sasaki Y, Fujimaki N, Ptz B (1999) Pre-SMA activation during sequence learning reflects visuo-motor association. J Neurosci 19:RC1: 1-6.
  • Nakamura K, Sakai K, Hikosaka O (1999) Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures. J Neurophysiol 82: 1063-1068.
  • Sakai K, Hikosaka O, Miyauchi S, Takino R, Tamada T, Iwata NK, Nielsen M (1999) Neural representation of a rhythm depends on its interval ratio. J Neurosci 19: 10074-10081.
  • Lu X, Hikosaka O, Miyachi S (1998) Role of monkey cerebellar nuclei in skill for sequential movement. J Neurophysiol 79: 2245-2254.
  • Nakamura K, Sakai K, Hikosaka O (1998) Neuronal activity in medial frontal cortex during learning of sequential procedures. J Neurophysiol 80: 2671-2687.
  • Kawagoe R, Takikawa Y, Hikosaka O (1998) Expectation of reward modulates cognitive signals in the basal ganglia. Nat Neurosci 5: 411-416.
  • Rand MK, Hikosaka O, Miyachi S, Lu X, Miyashita K (1998) Characteristics of a long-term procedural skill in the monkey. Exp Brain Res 118: 293-297.
  • Sakai K, Hikosaka O, Miyauchi S, Takino R, Sasaki Y, Ptz B (1998a) Transition of brain activation from frontal to parietal areas in visuo-motor sequence learning. J Neurosci 18: 1827-1840.
  • Sakai K, Takino R, Hikosaka O, Miyauchi S, Sasaki Y, Ptz B, Fujimaki N (1998b) Separate cerebellar areas for motor control. NeuroReport 9: 2359-2363.
  • Takikawa Y, Kawagoe R, Miyashita N, Hikosaka O (1998) Presaccadic omnidirectional burst activity in the basal interstitial nucleus in the monkey cerebellum. Exp Brain Res 121: 442-450.
  • Terao Y, Fukuda H, Ugawa Y, Hikosaka O, Hanajima R, Furubayashi T, Sakai K, Miyauchi S, Sasaki Y, Kanazawa I (1998) Visualization of the information flow through human oculomotor cortical regions by transcranial magnetic stimulation. J Neurophysiol 80: 936-946.
  • Horikawa HPM, Nakazato T, Hikosaka O (1997) Duration of catalepsy correlates with increased intrastriatal sulpiride. European Journal of Pharmacology 326: 15-21.
  • Miyachi S, Hikosaka O, Miyashita K, Kardi Z, Rand MK (1997b) Differential roles of monkey striatum in learning of sequential hand movement. Exp Brain Res 115: 1-5.
  • Nakahara H, Doya K, Hikosaka O, Nagano S (1997b) Multiple representations in the basal ganglia loops for sequential decision making. Technical Report of IEICE NC97-24: 97-104.
  • Shimojo S, Miyauchi S, Hikosaka O (1997) Visual motion sensation yielded by non-visually driven attention. Vision Res 37: 1575-1580.
  • Hikosaka O, Sakai K, Miyauchi S, Takino R, Sasaki Y, Ptz B (1996) Activation of human presupplementary motor area in learning of sequential procedures: A functional MRI study. J Neurophysiol 76: 617-621.
  • Kojima J, Matsumura M, Togawa M, Hikosaka O (1996) Tonic activity during visuo-oculomotor behavior in the monkey superior colliculus. Neurosci Res 26: 17-28.
  • Miyashita K, Rand MK, Miyachi S, Hikosaka O (1996a) Anticipatory saccades in sequential procedural learning in monkeys. J Neurophysiol 76: 1361-1366.
  • Miyashita N, Hikosaka O (1996) Minimal synaptic delay in the saccadic output pathway of the superior colliculus studied in awake monkey. Exp Brain Res 112: 187-196.
  • Hikosaka O, Rand MK, Miyachi S, Miyashita K (1995b) Learning of sequential movements in the monkey - Process of learning and retention of memory. J Neurophysiol 74: 1652-1661.
  • Iwamura Y, Tanaka M, Hikosaka O, Sakamoto M (1995) Postcentral neurons of alert monkeys activated by the contact of the hand with objects other than the monkey’s own body. Neurosci Lett 186: 127-130.
  • Kato M, Miyashita N, Hikosaka O, Matsumura M, Usui S, Kori A (1995) Eye movements in monkeys with local dopamine depletion in the caudate nucleus. I. Deficits in spontaneous saccades. J Neurosci 15: 912-927.
  • Kori A, Miyashita N, Kato M, Hikosaka O, Usui S, Matsumura M (1995) Eye movements in monkeys with local dopamine depletion in the caudate nucleus. II. Deficits in voluntary saccades. J Neurosci 15: 928-941.
  • Miyashita N, Hikosaka O, Kato M (1995b) Visual hemineglect induced by unilateral striatal dopamine deficiency in monkeys. NeuroReport 6: 1257-1260.
  • Hikosaka O, Miyauchi S, Shimojo S (1993c) Focal visual attention produces illusory temporal order and motion sensation. Vision Res 33: 1219-1240.
  • Hikosaka O, Miyauchi S, Shimojo S (1993e) Voluntary and stimulus-induced attention detected as motion sensation. Perception 22: 517-526.
  • Hikosaka O, Sakamoto M, Miyashita N (1993f) Effects of caudate nucleus stimulation on substantia nigra cell activity in monkey. Exp Brain Res 95: 457-472.
  • Iwamura Y, Tanaka M, Sakamoto M, Hikosaka O (1993) Rostrocaudal gradients in the neuronal receptive field complexity in the finger region of the alert monkey’s postcentral gyrus. Exp Brain Res 92: 360-368.
  • Matsumura M, Kojima J, Gardiner TW, Hikosaka O (1992) Visual and oculomotor functions of monkey subthalamic nucleus. J Neurophysiol 67: 1615-1632.
  • Usui S, Fukuda H, Hikosaka O (1990a) Spontaneous saccades in MPTP-induced hemi-parkinsonian monkeys. Clin Neurol 30: 1181-1189.
  • Hikosaka O, Sakamoto M, Usui S (1989a) Functional properties of monkey caudate neurons. I. Activities related to saccadic eye movements. J Neurophysiol 61: 780-798.
  • Hikosaka O, Sakamoto M, Usui S (1989b) Functional properties of monkey caudate neurons. II. Visual and auditory responses. J Neurophysiol 61: 799-813.
  • Hikosaka O, Sakamoto M, Usui S (1989c) Functional properties of monkey caudate neurons. III. Activities related to expectation of target and reward. J Neurophysiol 61: 814-832.
  • Sakamoto M, Hikosaka O (1989) Eye movements induced by microinjection of GABA agonist in the rat substantia nigra pars reticulata. Neurosci Res 6: 216-233.
  • Hikosaka O, Sakamoto M (1987) Dynamic characteristics of saccadic eye movements in the albino rat. Neurosci Res 4: 304-308.
  • Hikosaka O, Wurtz RH (1986) Saccadic eye movements following injection of lidocaine into the superior colliculus. Exp Brain Res 61: 531-539.
  • Hikosaka O, Sakamoto M (1986a) Cell activity in monkey caudate nucleus preceding saccadic eye movements. Exp Brain Res 63: 659-662.
  • Hikosaka O, Sakamoto M (1986b) Neural activities in the monkey basal ganglia related to attention, memory and anticipation. Brain Dev 8: 454-462.
  • Hikosaka O, Wurtz RH (1985a) Modification of saccadic eye movements by GABA-related substances. I. Effect of muscimol and bicuculline in the monkey superior colliculus. J Neurophysiol 53: 266-291.
  • Hikosaka O, Wurtz RH (1985b) Modification of saccadic eye movements by GABA-related substances. II. Effects of muscimol in monkey substantia nigra pars reticulata. J Neurophysiol 53: 292-308.
  • Hikosaka O, Tanaka M, Sakamoto M, Iwamura Y (1985) Deficits in manipulative behaviors induced by local injections of muscimol in the first somatosensory cortex of the conscious monkey. Brain Res 325: 1-2.
  • Iwamura Y, Tanaka M, Sakamoto M, Hikosaka O (1985b) Diversity in receptive field properties of vertical neuronal arrays in the crown of the postcentral gyrus of the conscious monkey. Exp Brain Res 58: 400-411.
  • Iwamura Y, Tanaka M, Sakamoto M, Hikosaka O (1985d) Vertical neuronal arrays in the postcentral gyrus signaling active touch: A receptive field study in the conscious monkey. Exp Brain Res 58: 412-420.
  • Hikosaka O, Wurtz RH (1983a) Effects on eye movements of a GABA agonist and antagonist injected into monkey superior colliculus. Brain Res 272: 368-372.
  • Hikosaka O, Wurtz RH (1983b) Visual and oculomotor functions of monkey substantia nigra pars reticulata. I. Relation of visual and auditory responses to saccades. J Neurophysiol 49: 1230-1253.
  • Hikosaka O, Wurtz RH (1983c) Visual and oculomotor functions of monkey substantia nigra pars reticulata. II. Visual responses related to fixation of gaze. J Neurophysiol 49: 1254-1267.
  • Hikosaka O, Wurtz RH (1983d) Visual and oculomotor functions of monkey substantia nigra pars reticulata. III. Memory-contingent visual and saccade responses. J Neurophysiol 49: 1268-1284.
  • Hikosaka O, Wurtz RH (1983e) Visual and oculomotor functions of monkey substantia nigra pars reticulata. IV. Relation of substantia nigra to superior colliculus. J Neurophysiol 49: 1285-1301.
  • Iwamura Y, Tanaka M, Sakamoto M, Hikosaka O (1983a) Converging patterns of finger representation and complex response properties of neurons in area 1 of the first somatosensory cortex of the conscious monkey. Exp Brain Res 51: 327-337.
  • Iwamura Y, Tanaka M, Sakamoto M, Hikosaka O (1983b) Functional subdivisions representing different finger regions in area 3 of the first somatosensory cortex of the conscious monkey. Exp Brain Res 51: 315-326.
  • Hikosaka O, Igusa Y (1980) Axonal projection of prepositus hypoglossi and reticular neurons in the brainstem of the cat. Exp Brain Res 39: 441-451.
  • Hikosaka O, Igusa Y, Imai H (1980a) Inhibitory connections of nystagmus-related reticular burst neurons with neurons in the abducens, prepositus hypoglossi and vestibular nuclei in the cat. Exp Brain Res 39: 301-311.
  • Hikosaka O, Nakao S, Shimazu H (1980b) Postsynaptic inhibition underlying spike suppression of secondary vestibular neurons during quick phases of vestibular nystagmus. Neurosci Lett 16: 21-26.
  • Ishimine S, Hikosaka O, Nakamura Y (1980) Spatio-temporal patterns of pre- and postsynaptic inhibition induced by primary afferent activation in the trigeminal sensory nucleus in cats. Exp Brain Res 40: 154-163.
  • Iwamura Y, Tanaka M, Hikosaka O (1980) Overlapping representation of fingers in area 2 of the monkey somatosensory cortex of the conscious monkey. Brain Res 197: 516-520.
  • Hikosaka O, Igusa Y, Imai H (1978a) Firing pattern of prepositus hypoglossi and adjacent reticular neurons related to vestibular nystagmus in the cat. Brain Res 144: 395-403.
  • Hikosaka O, Igusa Y, Nakao S, Shimazu H (1978b) Direct inhibitory synaptic linkage of pontomedullary reticular burst neurons with abducens motoneurons in the cat. Exp Brain Res 33: 337-352.
  • Hikosaka O, Maeda M, Nakao S, Shimazu H, Shinoda Y (1977) Presynaptic impulses in the abuducens nucleus and their relation to postsynaptic potentials in motoneurons during vestibular nystagmus. Exp Brain Res 27: 355-376.
  • Hikosaka O, Kawakami T (1977) Inhibitory reticular neurons related to the quick phase of vestibular nystagmus - their location and projection. Exp Brain Res 27: 377-396.
  • Hikosaka O, Kawakami T (1976) Inhibitory interneurons in the reticular formation and their relation to vestibular nystagmus. Brain Res 117: 513-518.
  • Hikosaka O, Maeda M (1973) Cervical effects on abducens motoneurons and their interaction with vestibulo-ocular reflex. Exp Brain Res 18: 512-530.

Reviews

Bromberg-Martin ES, Matsumoto M, Hikosaka O (2010) Dopamine in motivational control: rewarding, aversive, and alerting. Neuron 68:815-834.

Hikosaka O (2010) The habenula: from stress evasion to value-based decision-making. Nat Rev Neurosci 11:503-513.

Hikosaka O, Isoda M (2010) Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms. Trends Cogn Sci 14: 154-161.

Hikosaka O, Sesack SR, Lecourtier L, Shepard PD (2008) Habenula: crossroad between the basal ganglia and the limbic system. J Neurosci 28:11825-11829.

Hikosaka O, Bromberg-Martin E, Hong S, Matsumoto M (2008) New insights on the subcortical representation of reward. Curr Opin Neurobiol 18:203-208.

Hikosaka O (2008) [Decision-making and learning by cortico-basal ganglia network]. Brain Nerve 60:799-813.

Balleine BW, Delgado MR, Hikosaka O (2007) The role of the dorsal striatum in reward and decision-making. J Neurosci 27:8161-8165.

Hikosaka O (2007) Basal Ganglia Mechanisms of Reward-oriented Eye Movement. Ann N Y Acad Sci 1104:229-249.

Hikosaka O (2007) Habenula. Scholarpedia 2:2703. http://www.scholarpedia.org/article/Habenula

Hikosaka O (2007) GABAergic output of the basal ganglia. Prog Brain Res 160:209-226.

Hikosaka O, Nakamura K, Nakahara H (2006) Basal Ganglia orient eyes to reward. J Neurophysiol 95:567-584.

Sakai K, Hikosaka O, Nakamura K (2004) Emergence of rhythm during motor learning. Trends Cogn Sci 8:547-553.

Donoghue JP, Hikosaka O (2003) Motor systems. Curr Opin Neurobiol 13:643-646.

Hikosaka O (2002) A new approach to the functional systems of the brain. Epilepsia 43 Suppl 9:9-15.

Hikosaka O, Nakamura K, Sakai K, Nakahara H (2002) Central mechanisms of motor skill learning. Curr Opin Neurobiol 12: 217222.

Hikosaka O, Takikawa Y, Kawagoe R (2000) Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol. Rev. 80: 953-978.

Hikosaka O, Sakai K, Nakahara H, Lu X, Miyachi S, Nakamura K, Rand MK (1999) Neural mechanisms for learning of sequential procedures. In: The New Cognitive Neurosciences (Gazzaniga MS, eds), pp. 553-572, Cambridge, MA: The MIT Press.

Hikosaka O, Nakahara H, Rand MK, Sakai K, Lu X, Nakamura K, Miyachi S, Doya K (1999) Parallel neural networks for learning sequential procedures. Trends Neurosci 22: 464-471.

Hikosaka O (1999) Probing consciousness with an electrode. Brain Res Bull 50: 337-338.

Hikosaka O (1998b) Neural systems for control of voluntary action - a hypothesis. Advances in Biophysics 35: 81-102.

Hikosaka O, Miyashita K, Miyachi S, Sakai K, Lu X (1998) Differential roles of the frontal cortex, basal ganglia, and cerebellum in visuomotor sequence learning. Neurobiology of Learning and Memory 70: 137-149.

Hikosaka O, Miyauchi S, Shimojo S (1996e) Orienting of spatial attention - its reflexive, compensatory, and voluntary mechanisms. Cognitive Brain Research 5: 1-9.

Hikosaka O, Miyauchi S, Takeichi H, Shimojo S (1996f) Multimodal spatial attention visualized by motion illusion. In: Attention and Performance XVI : Information Integration in Perception and Communication (Inui T, McClelland J, eds), pp. 237-261. Cambridge, MA: MIT Press.

Hikosaka O, Miyauchi S, Shimojo S (1993d) Visual attention revealed by an illusion of motion. Neurosci Res 18: 11-18.

Hikosaka O (1991a) Basal ganglia - possible role in motor coordination and learning. Curr Opin Neurobiol 1: 638-643.

Hikosaka O (1989c) Role of basal ganglia in saccades. Rev Neurol (Paris) 145: 580-586.

Evarts EV, Kimura M, Wurtz RH, Hikosaka O (1984) Behavioral correlates of activity in basal ganglia neurons. Trends Neurosci 7: 447-453.

Book sections

Hikosaka O (2009) Basal Ganglia and Oculomotor Control. In: Squire LR (ed.)Encyclopedia of Neuroscience, volume 2, pp. 53-61. Oxford: Academic Press.

Nomura Y., Fukuda H., Terao Y., Hikosaka O., Segawa M. (2003) Abnormalities of voluntary saccades in Gilles de la Tourette’s syndrome: pathophysiological consideration. Brain Dev 25 Suppl 1: S48-54.

Shimojo S., Hikosaka O., Miyauchi S. (In press) Automatic and controlled processes of attention revealed in the line motion effect. In: Attention & Performance XV (Gopher D, Koirat A, eds), pp. Cambridge, MA: MIT Press.

Hikosaka O., Sakai K., Nakahara H., Lu X., Miyachi S., Nakamura K., Rand M.K. (1999) Neural mechanisms for learning of sequential procedures. In: The Cognitive Neurosciences (Gazzaniga MS, eds), pp. 553-572. Cambridge, MA: The MIT Press.

Hikosaka O., Miyachi S., Miyashita K., Rand M.K. (1996a) Learning of sequential procedures in monkeys. In: The Acquisition of Motor Behavior in Vertebrates (Bloedel JR, Ebner TJ, Wise SP, eds), pp. 303-317. Cambridge, MA: The MIT Press.

Hikosaka O., Miyachi S., Miyashita K., Rand M.K., Karadi Z. (1996b) Procedural learning in monkeys - possible roles of the basal ganglia. In: Perception, Memory, and Emotion: Frontier in Neuroscience (Ono T, McNaughton BL, Molotchnikoff S, Rolls ET, Nishijo H, eds), pp. 403-420. Oxford, UK: Elsevier.

Hikosaka O., Miyachi S., Miyashita K., Sakai K., Miyauchi S., Takino R., Sasaki Y., Ptz B. (1996c) Neural mechanisms of sequential procedural learning. In: Integrative and Molecular Approach to Brain Function (Ito M, Miyashita Y, eds), pp. 285-292. Amsterdam: Elsevier.

Hikosaka O., Miyashita K., Sakai K., Miyauchi S., Takino R., Sasaki Y., Ptz B. (1996d) Role of the medial frontal cortex in sequential procedural learning. In: Brain Processes and Memory (Ishikawa K, McGaugh JL, Sakata H, eds), pp. 299-306. Amsterdam: Elsevier.

Hikosaka O., Rand M.K., Miyashita K., Miyachi S. (1996g) Learning of sequential procedures in monkeys. In: Recent Advances in Clinical Neurophysiology (Kimura J, Shibasaki H, eds), pp. 296-303. Amsterdam: Elsevier.

Hikosaka O., Sakai K., Miyauchi S., Takino R., Sasaki Y., Ptz B. (1996j) Brain activation during learning of sequential procedures. In: Visualization of Information Processing in the Human Brain: Recent Advances in MEG and Functional MRI (Hashimoto I, Okada YC, Ogawa S, eds), pp. 245-252. Amsterdam: Elsevier.

Segawa M., Tanaka R., Nomura Y., Fukuda H., Hikosaka O. (1996) Saccadic eye movements in basal ganglia disorders. In: Recent Advances in Clinical Neurophysiology (Kimura J, Shibasaki H, eds), pp. 170-176. Amsterdam: Elsevier.

Shimojo S., Tanaka Y., Hikosaka O., Miyauchi S. (1996) Vision, attention, and action: Inhibition and facilitation in sensory-motor links revealed by the reaction time and the line motion. In: Attention and Performance XVI : Information Integration in Perception and Communication (Inui T, McClelland J, eds), pp. 597-630. Cambridge, MA: MIT Press.

Hikosaka O. (1995) Neural mechanisms of saccadic eye movement. In: Vertigo, Nausea, tinnitus and Hearing Loss in Central and Peripheral Vestibular Diseases. Proceedings of the XXIInd Annual Meeting of the International Neurootological and Equilibriometric Society. (Claussen C-F, Sakata E, Itoh A, eds), pp. 3-18. Amsterdam: Elsevier.

Hikosaka O., Fukuda H., Segawa M., Nomura Y. (1995a) Voluntary saccades in normal and in dopamine deficient subjects. In: Age-Related Dopamine-Deficient Disorders (Segawa M, Nomura Y, eds), pp. 59-68. Basal: Karger.

Hikosaka O., Rand M.K., Miyachi S,. Miyashita K. (1995c) Procedural learning in the monkey. In: Functions of the Cortico-Basal Ganglia Loop (Kimura M, Graybiel AM, eds), pp. 18-30. Tokyo: Springer.

Kato M., Hikosaka O. (1995) Function of the indirect pathway in the basal ganglia oculomotor system: visuo-oculomotor activities of external pallidum neurons. In: Age-Related Dopamine-Deficient Disorders (Segawa M, Nomura Y, eds), pp. 178-187. Basal: Karger.

Hikosaka O. (1994) Role of basal ganglia in control of innate movements, learned behavior and cognition - a hypothesis. In: The Basal Ganglia IV: New Ideas and Data on Structure and Function (Percheron G, McKenzie JS, Fger J, eds), pp. 589-596. New York: Plenum Press.

Segawa M., Hikosaka O., Fukuda H., Uetake K. (1994) Deficits in saccadic eye movements in basal ganglia disorders. In: The Basal Ganglia IV: New Ideas and Data on Structure and Function (Percheron G, McKenzie JS, Feger J, eds), pp. 525-531. New York: Plenum Press.

Hikosaka O., Matsumura M., Kojima J., Gardiner T.W. (1993b) Role of basal ganglia in initiation and suppression of saccadic eye movements. In: Role of the Cerebellum and Basal Ganglia in Voluntary Movement (Mano N, Hamada I, DeLong MR, eds), pp. 213-219. Amsterdam: Elsevier.

Hikosaka O. (1993) Role of the basal ganglia in motor learning: a hypothesis. In: Brain Mechanisms of Perception and Memory (Ono T, Squire LR, Raichle ME, PerrettD.I., Fukuda M, eds), pp. 497-513. New York: Oxford University Press.

Hikosaka O., Fukuda H., Kato M., Uetake K., Nomura Y., Segawa M. (1993a) Deficits in saccadic eye movements in hereditary progressive dystonia with marked diurnal fluctuation. In: Hereditary Progressive Dystonia with Marked Diurnal Fluctuation (Segawa M, eds), pp. 159-177. Lancs & New York: The Parthenon Publishing Group.

Hikosaka O., Imai H., Segawa M. (1992) Saccadic eye movements in parkinsonism. In: Vestibular and Brain Stem Control of Eye, Head and Body Movements (Shimazu H, Shinoda Y, eds), pp. 405-414. Tokyo: Japan Scientific Society Press.

Hikosaka O. (1991b) Role of the forebrain in oculomotor function. In: Role of the Forebrain in Sensation and Behavior (Holstege G, eds), pp. 101-107. Amsterdam: Elsevier.

Hikosaka O. (1989a) Motor programming in basal ganglia. In: Neural Programming (Ito M, eds), pp. 101-109. Tokyo: Japan Scientific Societies Press.

Hikosaka O. (1989b) Role of basal ganglia in initiation of voluntary movements. In: Dynamic Interactions in Neural Networks: Models and Data (Arbib MA, Amari S, eds), pp. 153-167. New York: Springer-Verlag.

Hikosaka O., Wurtz R.H. (1989) The basal ganglia. In: The Neurobiology of Saccadic Eye Movements (Wurtz RH, Goldberg ME, eds), pp. 257-281. Amsterdam: Elsevier.

Hikosaka O., Segawa M., Imai H. (1987) Voluntary saccadic eye movement: application to analyze basal ganglia disease. In: Highlights in Neuro-Ophthalmology (Ishikawa S, eds), pp. 133-138. Amsterdam: Aeolus Press.

Nomura Y., Segawa M., Soda M., Hikosaka O. (1987) Voluntary saccadic eye movements in basal ganglia disorders. In: Highlights in Neuro-Ophtha

Last Reviewed: 
June 2015