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Laboratory of Immunology

Mission Statement

Serpiginous choroiditis with extensive scarring

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The goal of the Laboratory of Immunology is to perform cutting edge, quality research in immunology and infectious diseases that is designed to better understand the normal physiologic state and the processes which perturb it, with special emphasis on inflammatory mechanisms in the eye as a model system. In pursuit of this goal we capitalize on the unique research environment at NIH and the constant interaction between clinician and basic researcher. We recognize and support creativity and individualism under the umbrella of programmatic needs in order to maintain a strong basic research portfolio and achieve the rapid translation of insights gleaned from that research to the bedside.

NEI Remembers Robert Nussenblatt (1948-2016)

Clinical Immunology Section

Section Chief: Robert Nussenblatt, M.D.

The Section’s interest is focused on the immunological mechanisms involved in ocular pathology including endogenous and exogenous uveitis, systemic diseases associated with uveitis (such as sarcoidosis, Behcet’s disease) and ocular neoplasias (particularly ocular lymphoma) and age related macular degeneration.

Experimental Immunology Section

Section Chief: Igal Gery, Ph.D.

The research carried out by the Section addresses issues related to mechanisms, cells and molecules that participate in the induction or modulation of ocular inflammation.

Immunoregulation Section

Section Chief: Rachel Caspi, Ph.D.

The Section’s interest is in cellular and molecular mechanisms involved in immune and autoimmune responses affecting the eye and vision.

Molecular Immunology Section

Section Chief: Charles Egwuagu, Ph.D.

The Section’s work has focused on understanding molecular and cellular mechanisms that regulate immune homeostasis, with particular emphasis on epigenetic mechanisms that regulate lymphocyte development and cell-fate decisions and roles played by pro-inflammatory and anti-inflammatory cytokines in the development of central nervous system (CNS) inflammatory diseases.

Last Reviewed: 
April 2016