Immunopathology Section

Age-related retinal degeneration

Senescent Ccl2-/- mice are shown to develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single nucleotide polymorphisms within CX3CR1 are also associated with age-related macular degeneration (AMD). We generated mice deficient in both genes on rd8 background mice. The genetic targeted mice spontaneously developed AMD-like retinal lesions such as focal photoreceptor degeneration, choroidal neovascularization, A2E accumulation in the retinal pigment epithelium (RPE), and complement deposits in the Bruch”s membrane. (Tuo, et al. Invest Ophthalmol Vis Sci 2007;48:3827-36.)

Multiple yellow, round subretinal lesions mimicking drusen in the fundus.
Multiple yellow, round subretinal lesions mimicking drusen in the fundus.
Neovascular vessels from the choroids breaking through Bruch's membrane into the retina.
Neovascular vessels from the choroids breaking through Bruch’s membrane into the retina.
Many lipofusin (pale translucent substance) deposits in the RPE cells and few linear deposits in the Bruch's membrane.
Many lipofusin (pale translucent substance) deposits in the RPE cells and few linear deposits in the Bruch’s membrane.

Last Reviewed: April 2012