Immunopathology Section

Recent Publications

Selected Review Articles

C.C. Chan, Q. Li: Immunopathology of uveitis. Br J Ophthalmol 82:91-96, 1998. PubMed

G. Adamus, C.C. Chan: Experimental autoimmune uveitides: Multiple antigens, diverse diseases. In Caspi, R.R. (ed.): The eye: Immunity and autoimmunity. Int Rev Immunol 21:209-229, 2002. PubMed

C.C. Chan: Molecular pathology of primary intraocular lymphoma. Trans Am Ophthalmol Soc 101:275-292, 2003. PubMed

J. Tuo, C.M. Bojanowski, C.C. Chan: Genetic factors of age-related macular degeneration. Prog Ret Eye Res 23:229-249, 2004. PubMed

C.C. Chan, J.A. Gonzales: Primary Intraocular Lymphoma. World Scientific Publishing Co., Singapore, London, Hackensack NJ, 2007. World Scientific

M. Patel, C.C. Chan: Immunopathological aspects of age-related macular degeneration. Sem Immunopathol 30:97-110, 2008. PubMed

X. Ding, X. Ding, M. Patel, C.C. Chan: Molecular pathology of age-related macular degeneration. Prog Ret Eye Res 28:1-18, 2009. PubMed

H.L. Ramkumar, J. Zhang, C.C. Chan: Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Ret Eye Res 29:169-190, 2010. PubMed

Y. Wang, V.M. Wang, C.C. Chan: The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment. Eye 25:127-139, 2011. PubMed

C.C. Chan, J.L. Rubenstwin, S.E. Coupland, J.L. Davis, J.W. Harbour, P.B. Johnston, N. Cassoux, V. Touitou, J.R. Smith, T.T. Batchelor, J.S. Pulido: Primary vitreoretinal lymphoma: A report from an international primary central nervous system lymphoma collaborative group symposium. The Oncologist 16:1589-1599, 2011. PubMed

D. Ardeljan, C.C. Chan: Aging is not a disease: Distinguishing age-related macular degeneration from aging. Prog Ret Eye Res 37:68-89, 2013. PubMed

Peer Reviewed Journal Articles (Recent Three Years)

J. Tuo, S. Grob, K. Zhang, C.C. Chan: Genetics of immunological and inflammatory components in age-related macular degeneration. Ocul Immunol Inflamm 20:27-36, 2012. PubMed

J. Tuo, X. Cao, D. Shen, Y. Wang, J. Zhang, J.Y. Oh, D.J. Prockop, C.C. Chan: Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model. J Neuroinflamm 9:59, 2012. PubMed

S. Park, C.C. Chan: Von Hippel-Lindau disease (VHL): A need for a murine model with retinal hemangioblastoma. Histol Histopathol 27:975-984, 2012. PubMed

M.E. Aronow, G. Adamus, M. Abu-Asab, Y. Wang, C.C. Chan, A.D. Singh: Paraneoplastic vitelliform retinopathy: Clinicopathologic correlation and review of the literature. Surv Ophthalmol 57:558-564, 2012. PubMed

M.J. Mattapalli, E.F. Wawrousek, C.C. Chan, H. Zhao, J.Roychoudhury, T.A. Ferguson, R.R. Caspi: The rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 53:2921-2927, 2012. PubMed

H.L. Ramkumar, D.F. Shen, J. Tuo, R.M. Braziel, S.E. Coupland, J.R. Smith, C.C. Chan: IL-10 -1082 SNP and IL-10 in primary CNS and vitreoretinal lymphoma. Graefe’s Arch Clin Exp Ophthalmol 250:1541-1548, 2012. PubMed

N. Nagarkatti-Gude, Y. Wang, M.J. Ali, S.G. Honavar, M.J. Jager, C.C. Chan: Genetics of primary intraocular tumors. Ocul Immunol Inflamm 20:244-254, 2012. PubMed

B. Liu, C.C. Chan, R.B. Nussenblatt: Application of Small Molecules/Macromolecules in Ocular Inflammatory Diseases. Anti-inflamm Anti-allergy Agents Med Chem 11:113-120, 2012. PubMed

Y. Wang, D. Shen, V.M. Wang, C.R. Yu, R.X. Wang, J. Tuo, C.C. Chan: Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress. Apoptosis 17:1144-1155, 2012. PubMed

M.M. Liu, C.C. Chan, J. Tuo: Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics. Hum Genomics 6:13, 2012. PubMed

V.M. Wang, R.B. Rosen, C.B. Meyerle, S.K. Kurup, D. Ardeljan, E. Agron, K. Tai, M. Pomykala, E.Y. Chew, C.C. Chan, J. Tuo: Suggestive association between PLA2G12A SNP rs2285714 and response to anti-VEGF therapy in patients with exudative age-related macular degeneration. Mol Vis 18:2578-2585, 2012. PubMed

X.K. Chu, J. Tuo, C.C. Chan: Genetics of AMD: application to drug design. Future Med Chem 5:13-15, 2013. PubMed

Y. Wang, M.S. Abu-Asab, W. Li, M.E. Aronow, A.D. Singh, C.C. Chan: Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy. BMC Ophthalmol 12:56, 2012. PubMed

L. Wei, B. Liu, J. Tuo, D. Shen, P. Chen, Z. Li, X. Liu, J. Ni, P. Dagur, H.N. Sen, S. Jawad, D. Ling, S. Park, S. Chakrabarty, C. Meyerle, E. Agron, F.L. Ferris 3rd, E.Y. Chew, J.P. McCoy, E. Blum, P.J. Francis, M.L. Klein, R.H. Guymer, P.N. Baird, C.C. Chan, R.B. Nussenblatt: Hypomethylation of IL17RC promoter associates with age-related macular degeneration. Cell Report 2:1151-1158, 2012. PubMed

X.K. Chu, Y. Wang, D. Ardeljan, J. Tuo, C.C. Chan: Controversial view of a genetically altered mouse model of focal retinal degeneration. Bioengineered 4(3), 2013. PubMed

D. Ardeljan, C.B. Meyerle, E. Agron, J.J. Wang, P. Mitchell, E.Y. Chew, J. Zhao, A. Maminishkis, C.C. Chan, J. Tuo: Influence of TIM3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration. Eur J Hum Genet 21:1152-1157, 2013. PubMed

C.C. Chan, H.N. Sen: Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma. Discov Med 15:93-100, 2013. PubMed

J. Zhang, J. Tuo, X. Cao, D. Shen, W. Li, C.C. Chan: Early degeneration of photoreceptor synapse in Ccl2/Cx3cr1 deficient mice on Crb1rd8 background. Synapse 67:515-531, 2013. PubMed

H.L. Ramkumar, J. Tuo, D.F. Shen, J. Zhang, X. Cao, E.Y. Chew, C.C. Chan: Nutrient supplementation with n-3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1 deficient mice on Crb1rd8 background. J Nutr 143:1129-1135, 2013. PubMed

Y. Wang, B.E. Marciano, D. Shen, R.J. Bishop, S. Park, S.M. Holland, C.C. Chan: Molecular identification of bacterial DNA in the chorioretinal scars of chronic granulomatous disease. J Clin Immunol 33:917-924, 2013. PubMed

X.K. Chu, C.C. Chan: Sympathetic ophthalmia: to the 21st century and beyond. J Ophthalmic Inflamm Infect 3:49, 2013. Springer

M.D. Dalal, C.W. Morgans, R.M. Duvoisin, E.A. Gamboa, B. Jeffrey, S. Garg, C.C. Chan, H.N. Sen: Diagnosis of occult melanoma using TRPM1 autoantibody testing: A novel approach. Ophthalmology 120:2560-2564, 2013. PubMed

M.M. Liu, C.C. Chan, J. Tuo: Epigenetics in ocular diseases. Curr Genomics 14:166-172, 2013. PubMed

M.S. Abu-Asab, J. Salazar, J. Tuo, C.C. Chan: A systems biology subtyping of AMD on the basis of gene expression. J Ophthalmol 2013:453934, 2013. PubMed

N. Popp, X.K. Chu, D. Shen, J. Tuo, C.C. Chan: Evaluating potential therapies in a mouse model of focal retinal degeneration with age-related macular degeneration (AMD)-like lesions. J Clin Exp Ophthalmol 4(5):1000296, 2013. PubMed

Y. Wang, P. Subramanian, D. Shen, J. Tuo, S.P. Beccerra, C.C. Chan: Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration. ASN Neuro 5(5):00126, 2013. PubMed

J. Tuo, D. Shen, H.H. Yang, C.C. Chan: Distinct microRNA-155 expression in the vitreous of patients with primary vitreoretinal lymphoma and uveitis. Am J Ophthalmol 157:728-734, 2014. PubMed

Y. Wang, C.C. Chan: Gender differences in Vogt-Koyanagi-Harada disease and sympathetic ophthalmic. J Ophthalmol 2014:157803, 2014. PubMed

X.K. Chu, C.B. Meyerle, X. Liang, E.Y. Chew, C.C. Chan, J. Tuo: In-depth analyses unveil the association and possible functional involvement of novel RAD51B polymorphisms in age-related macular degeneration. Age 36:9627, 2014. PubMed

Y. Wang, M.S. Abu-Asab, C.R. Yu, Z. Tang, D. Shen, J. Tuo, X. Li, C.C. Chan: Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration. Lab Invest 94:674-682, 2014. PubMed

D. Ardeljan, Y. Wang, S. Park, D. Shen, X.K. Chu, C.R. Yu, M. Abu-Asab, J. Tuo, C.G. Eberhart, T.W. Olsen, R.F. Mullins, G. White, S. Wadsworth, A. Scaria, C.C. Chan: Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interlukin-17 receptor acting as a cytokine blocker: implication for age-related macular degeneration. PLoS One 9(4):e95900, 2014. PubMed

Y. Wang, M.S. Abu-Asab, D. Shen, Z. Zhuang, E.Y. Chew, C.C. Chan: Upregulation of hypoxia-inucible factors and authophagy in von Hippel-Lindau-assocaited retinal hemangioblastoma. Graefe’s Arch Clin Exp Ophthalmol 252:1319-1327, 2014. PubMed

A.J. Ogilvy, D.F. Shen, Y. Wang, C.C. Chan, M. Abu-Asab: Implications of DNA leakage in eyes of mutant mice. Ultrastruct Pathol 38:335-343, 2014. PubMed

S. Chen, N.A. Popp, C.C. Chan: Animal models of age-related macular degeneration and their translatability into the clinic. Exp Rev Ophthalmol 9:285-295, 2014. Informa Healthcare

C.C. Chan, D.A. Goldstein, J.L. Davis, H.N. Sen: Editorial: Gender and uveitis. J Ophthalmol 2014:818070, 2014. PubMed

S. Chen, M.E. Aronow, C. Wang, D. Shen, C.C. Chan: Classical pathology of sympathetic ophthalmia presented in a unique case. Open Ophthalmol J 8:32-38, 2014. PubMed

S. Chen, K.J. Malik, D. Shen, C.C. Chan: Acute retinal necrosis with multiple viral infections: A case report. Int J Ophthalmic Pathol 3:5, 2014. SciTechnol

Supplemental Materials

V.M. Wang, J. Tuo, C.C. Chan: Chapter 3. Animal models to evaluate ocular nanoparticular drug delivery systems. In Ocular Drug Delivery: Barriers and Application of Nanoparticular Systems. D. Thassu, G. Chader (eds). Taylor & Francis, Oxford, UK. 2012; pp. 41-58. Taylor & Francis

C.C. Chan, W.M. Smith: Chapter 25. Inflammatory response and mediators in retinal injury. In Retina Fifth Edition. S.J. Ryan, A.P. Schachat, C.P. Wilkinson, D.R. Hintinm S. Sadda, P. Wiedemann (eds). Elsevier. London, UK. 2013; pp. 553-561. Elsevier

H.N. Sen, C.C. Chan: 7.23. Masquerade syndromes: neoplasms. Section 9: Masquerade symdormes. in Ophthalmology, Part 7: Uveitis and Other Intraocular Inflammations. N.A. Rao (Section editor), M. Yanoff, Duker (eds). Fourth edition. Elsevier, London, UK 2014; pp. 788-792. Elsevier

I. Gery, C.C. Chan: 7.2. Mechanisms of uveitis. Section 1: Basic Principles. in Ophthalmology, Part 7: Uveitis and Other Intraocular Inflammations, N.A. Rao (Section editor), M. Yanoff, Duker (eds). Fourth edition. Elsevier, London, UK 2014; pp.690-693. Elsevier

Y. Wang, C.C. Chan: Chapter 10. Ocular and adnexal T-cell lymphoma. In Ocular and Adnexal Lymphoma: Practical Consideration. A.D. Singh (ed); Springer-Verlag, Heidelberg, Germany 2013; pp.103-115. Springer

C.C. Chan, D. Ardeljan: Chapter 25. Molecular patholofy of macrophage and IL-17 in age-related macular degeneration. In Retinal Degenerative Diseases. J. Ash, J.G. Hollyfield, M.M. LaVail, R.E. Anderson, C. Grimm, C.B. Rickman (eds). Advances in Experimental Medicine and Biology 801, Springer-Verlag, Heidelberg, Germany 2014; pp193-198. Springer

C.C. Chan, D.A. Goldstein, J.L. Davis, H.N. Sen: Gender and Uveitis. Special issue. J Ophthalmol 2014; 815095. Hindawi

Last Reviewed: 
December 2014