2008 Focus on Fellows Program

Program

Twinbrook Campus
Conference Room 508, Terrace Level
5635 Fishers Lane, Rockville

Thursday October 30, 2008

Time Session
8:00 AM-8:30 AM Registration
Name badges and program booklets will be distributed
8:30 AM-8:45 AM Welcome Remarks
Sheldon Miller, Scientific Director, NEI
8:45 AM-9:25 AM Clinical Trials: More than an Assessment of Treatment Effect
Frederick Ferris, NEI Clinical Director
9:30 AM-10:00 AM Training session # 1 The normal eye: anatomy and physiology
Catherine Meyerle, Retina Staff Clinician, Clinical Trials Section, Office of the Clinical Director, NEI
10:00 AM-10:30 AM Training session #2 Flow Cytometry: when to use it and what do we learn from it?
Rafael Villasmil, Manager and Operator, NEI Flow Cytometry Core
10:30 AM-10:45 AM Break
  Oral Presentations
10:45 AM-11:10 AM #1. The relationship between spatial selection and object recognition in covert visual search.
Ilya E. Monosov, and Kirk G. Thompson, Unit on Visuomotor Integration, Laboratory of Sensorimotor Research
11:10 AM-11:35 AM #2. Recovery of RPE65 mutations: Studies of low activity mutants.
Alicia Acitores; Susan Gentleman; Eugenia Poliakov; Preethi Chander and T. Michael Redmond, Molecular Mechanisms Section, Laboratory of Retinal Cell and Molecular Biology
11:35 AM-12:00 PM #3. Dicer and microRNAs are essential for development of lens and cornea in mice.
Yan Li, and Joram Piatigorsky, Section on Molecular Genetics, Laboratory of Molecular and Development Biology
12:00 PM-12:25 PM #4. VEGF-B is an apoptosis inhibitor by suppression of BH3-only protein gene expression via VEGFR-1
Fan Zhang1, Yang Li1, Nobuo Nagai, Zhongshu Tang1, Johan Lennartsson, Kevin G. Becker, Andrew Nash4, Carl-Henrik Heldin, Xuri Li1National Eye Institute, Unit on Retinal Vascular Neurobiology Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan. TRIAD Technology Center, National Institute on Aging, NIH, Baltimore, Maryland, USA. CSL Limited, Parkville, Victoria, Australia. Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.
12:30 PM-1:10 PM
And
1:15 PM-1:50 PM
Lunch : Round Table Discussions with NEI Scientists

# 1. Proof of concept: From in vitro to in vivo assays; protein therapeutics to the choroidretinaJuan Amaral, staff scientist, Protein Structure and Function Section, Laboratory of Retinal Cell and Molecular Biology

#2. Protein-protein interactions in retina function and diseasePat Becerra, Protein Structure and Function Section Chief, Laboratory of Retinal Cell and Molecular Biology

#3. Starting a labBrian Brooks, Tenure-track Investigator, Ophthalmic Genetics and Visual Function Branch

#4. Clinical research at NEIEmily Chew, Deputy Director, Division of Epidemiology and Clinical Applications and Frederick Ferris, NEI Clinical Director

#5. Paths of success in scienceRichard Fisher, Director, Office of Program Panning and Analysis, and Sarah Sohraby, NEI Deputy Scientific Director

#6. Retinal PhysiologyWei Li, Tenure-track investigator, Unit on Retinal Neurophysiology

#7. Clinical immunology and epigeneticsZhuqing Li, staff scientist, Clinical Immunology section, Laboratory of Immunology

#8. Ethical issues in the laboratorySheldon Miller, NEI Scientific Director

#9. Retinal development and diseaseAnand Swaroop, Chief, Neurobiology-Neurodegeneration and Repair Laboratory

#10. When the results from mouse models are different from that of human samplesCheng Rong Yu, staff scientist, Molecular Immunology Section, Laboratory of Immunology

2:00 PM-2:30 PM Training session # 3 : Genetic engineering
Lijin Dong, lead investigator, NEI Genetic Engineering Facility
  Training
2:30 PM-3:00 PM The NEI intramural training program : what to expect from it and what it expects from you
Sarah Sohraby, Deputy Scientific Director
  Oral Presentations
3:00 PM-3:25 PM # 5. Inflammatory processes induced by TH1 or TH17 cells remarkably differ in heir kinetics, apparently due to differences in their susceptibility to reactivation induced cell death (RICD).
Guangpu Shi1, Barbara P. Vistica1, Madhu Ramaswamy, Cuiyan Tan1, Eric F. Wawrousek, Richard M. Siegel and Igal Gery11Laboratory of immunology, Laboratory of Molecular and Developmental Biology, NEI/NIH; Immunoregulation Unit, Autoimmunity Branch, NIAMS/NIH
3:30 PM-3:55 PM #6. Phagocytosis Defects associated with the Choroideremia CHM Gene
Wadih Zein, Strunnikova N, Gordiyenko N, Sui H, Macdonald I., Ophthalmic Genetics and Visual Function Branch
4:00 PM-4:25 PM #7. Intravitreal administration of AAV8 RS1 vector to the RS1-KO mouse results in cell type-specific retinoschisin expression and morphological improvement
Zhijian Wu , Tae Kwann Park, Sten Kjellstrom, Yong Zeng, Ronald A. Bush, Paul A. Sieving1, Peter Colosi1
Unit on Ocular gene Therapy, National Eye Institute and 2National Institute on Deafness and Other Communication Disorders
4:25 PM-4:55 PM #8. Genetic Screen for a Novel Autosomal Dominant Retinitis Pigmentosa (ADRP) Gene.
James S Friedman1, M. Brooks11, R. Khanna, E.H. Trager, K.E. Branham, V. Ponjavic, L. Grnse, G.R. Abecasis, S. Andréasson, A. Swaroop1, 1Neurobiology-Neurodegeneration and Repair Laboratory; Department of Ophthalmology, University of Michigan, Ann Arbor MI; Department of Ophthalmology, Lund University Hospital, Lund, Sweden; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI

Friday October 31, 2008

Time Session
9:00 AM-9:45 AM Key note lecture “Fulfilling the Promise of a Sequenced Human Genome”
Eric Green, Scientific Director, National Human Genome Research Institute
10:00 AM-10:30 AM Training session #4: The Electroretinogram (ERG)
Rafael Caruso, Staff Clinician, Ophthalmic Genetics and Visual Function Branch, NEI
10:30 AM-10:45 AM Break
  Oral Presentations
10:30 AM-10:45 AM Break
10:45 AM-11:10 AM #9. Association of RAGE and HTRA1 gene polymorphisms with diabetic retinopathy in type 2 diabetes
Suganthalakshmi Balasubbu, Sundaresan P, Kim R, Anand R, Namperumalsamy P, Hejtmancik JF, Molecular Genetics Section, Ophthalmic Genetics and Visual Function Branch
11:15 AM-11:40 AM #10. Stem cells and DNA methylation insights into retinal cell therapies and development
Igor Nasonkin, and A. Swaroop, Neurobiology-Neurodegeneration and Repair Laboratory
11:45 AM-12:10 PM #11. STAT1 inhibits ocular inflammatory disease by inducing Dendritic cells (DC) and Retinal cells to produce IL-27
Yun Sang Lee, Cheng-Rong Yu, Ahjoku Amadi-Obi and Charles E. EgwuaguMolecular Immunology Section, Laboratory of Immunology
12:15 PM-12:45 PM Lunch
  Career Development
12:45 PM-2:30 PM Set Your Sight on Success
Lori Conlan, Director, Office of Postdoctoral Services, Office of Intramural Training and Education (OITE), NIH

See-zing NIH Opportunities
Pat Sokolove, Deputy Director, OITE, NIH

Technology Transfer and Business Development: Career Opportunities for Scientists Steve Ferguson, Deputy Director, NIH Office of Technology

Educational and teaching Opportunities through the Foundation for advanced Education in the Sciences (FAES)
Robert Adelstein, Chief, laboratory of Molecular Cardiology, GDBC, NHLBI

2:30 PM-2:45 PM Break
  Oral Presentations
2:45 PM-3:10 PM #12. Cdk5 Activity Regulates Stress Fiber Organization and Contraction by Controlling Rho-Activation and Rho-Dependent Myosin Phosphorylation
Brajendra K. Tripathi and Peggy S. Zelenka, Laboratory of Molecular and Developmental Biology, Section on Cellular Differentiation.
3:15 PM-3:40 PM #13. 7-Ketocholesterol is present in oxidized lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation
Ignacio M. Larrayoz E.F. Moreira, J.W. Lee, I.R. Rodriguez, Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology
3:40 PM-4:05 PM #14. Role of the lateral habenula in motivational control of animal behaviors
Masayuki Matsumoto, and Okihide, Hikosaka, Neuronal networks Section, Laboratory of Sensorimotor Research
4:10 PM-4:45 PM Ethics in the Conduct of Research How It Applies to You
Joan Schwartz, Assistant Director, Office of Intramural Research, Office of the Director, NIH
4:45 PM-5:00 PM AWARDS Presentation
Paul Sieving, Loré Anne McNicol, and Sheldon Miller