Iridocorneal Endothelial (ICE) syndrome has three main features: (1) visible changes in the iris, the colored part of the eye that regulates the amount of light entering the eye; (2) swelling of the cornea; and (3) the development of glaucoma, a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly. ICE is usually present in only one eye.
ICE syndrome is actually a grouping of three closely linked conditions: iris nevus (or Cogan-Reese) syndrome; Chandler’s syndrome; and essential (progressive) iris atrophy. The most common feature of this group of diseases is the movement of endothelial cells off the cornea onto the iris. This loss of cells from the cornea often leads to corneal swelling, distortion of the iris, and variable degrees of distortion of the pupil, the adjustable opening at the center of the iris that allows varying amounts of light to enter the eye. This cell movement also plugs the fluid outflow channels of the eye, causing glaucoma. This condition is more common in women and usually diagnosed between ages 30-50.
For more information from other health sites, please visit the following webpages:
National Organization for Rare Disorders, Chandler’s Syndrome
Massachusetts Eye and Ear Infirmary, ICE Syndrome
For more information about the cornea and corneal diseases from the National Eye Institute, please visit the following webpage:
Facts About the Cornea and Corneal Disease
For information about glaucoma from the National Eye Institute, please visit the following webpage:
Facts About Glaucoma