“It would be fantastic if…”
The AGI began with the Audacious Goals Challenge, a prize competition that challenged participants to imagine the greatest achievement for vision research during the next 10-15 years. The challenge attracted more than 450 innovative proposals from around the world. The NEI consolidated the proposals into six themes, which were further explored by leading scientists at the Audacious Goals Development Meeting. In consultation with the National Advisory Eye Council, the NEI chose to pursue the goal of restoring vision through the regeneration of neurons and neural connections in the eye and visual system, specifically targeting the photoreceptors and retinal ganglion cells.
AGI Steering Committee
The AGI Steering Committee plots the scientific trajectory of the AGI. Consisting of three to five leading researchers, the steering committee is responsible for identifying knowledge gaps and the scientific expertise needed to bridge them. The steering committee currently comprises four members:
Mark S. Blumenkranz, M.D., is the H.J. Smead Professor of Ophthalmology, Emeritis, Stanford University Department of Ophthalmology. A surgeon, he investigates new approaches to the diagnosis and treatment of retinal disease.
Joshua Sanes, Ph.D., is the Paul J. Finnegan Family Director and Jeff C. Tarr Professor of Molecular and Cellular Biology at Harvard University. He studies how neural circuits in the eye and brain form and process information.
Clive Svendsen, Ph.D., is the Kerry and Simone Vickar Family Foundation Distinguished Chair in Regenerative Medicine at the Cedars-Sinai Regenerative Medicine Institute. He leads a group that stem cells to study and model neurodegenerative diseases and potential treatments.
Russ VanGelder, M.D., Ph.D., is the Boyd K. Bucey Memorial Chair and professor and chairman of the Department of Ophthalmology at University of Washington. His lab is investigating the therapeutic potential of synthetic small molecule photoswitches for restoring light sensitivity to degenerated retinas.
Rachel Wong, Ph.D., is a professor at the University of Washington Department of Biological Structure. Her lab studies developmental mechanisms that shape synaptic connectivity in the central nervous system using the retina as a model.
National Advisory Eye Council
The National Advisory Eye Council (NAEC) provides administrative guidance to the NEI. The NAEC consists of 12 recognized leaders in the fields of ophthalmology, optometry, and basic sciences. The NAEC advises the NEI director on AGI funding plans and provides a second level of review on proposals to AGI funding opportunities. More about the NAEC.
AGI Office at NEI
The AGI Office, led by Steven Becker, Ph.D., provides logistical support for all AGI-related activities.
AGI Working Group
The AGI Working Group comprises NEI staff within the Division of Extramural Science Programs, who help draft funding announcements, monitor the progress of research programs, and make recommendations to the AGI Steering Committee, the NAEC, and the NEI Director.
Donald F. Everett, M.A., directs the NEI program on collaborative clinical research.
Thomas N. Greenwell, Ph.D., directs the NEI program on retinal neuroscience.
Michael A. Steinmetz, Ph.D., directs the NEI Division of Extramural Science Programs
Cheri L. Wiggs, PhD., directs the NEI portfolios on perception and psychophysics, low vision, and blindness rehabilitation.
Contact the AGI
For more information, email NEIAudaciousGoal@nih.gov.