Optical Coherence-Based Imaging and Sensing in Biomedicine and Biotechnology
Joseph A. Izatt
Optical coherence-based imaging techniques including optical coherence tomography (OCT), optical coherence microscopy (OCM), and spectral domain phase microscopy (SDPM) use low-coherence spectral interferometry to obtain nanometer to micron-scale measurements of structure, motion, and molecular composition in living cells, tissues, and organisms. OCT has become a standard diagnostic tool in clinical ophthalmology, and is undergoing clinical trials for other human diagnostic applications including cancer detection and evaluation of cardiovascular disease. Within the past few years, dramatic technology advances have increased the performance of OCT and OCM systems manyfold, and are now capable of micron-scale two and three-dimensional functional and molecular imaging noninvasively in living systems. Functional extensions of OCT for Doppler blood flow imaging, polarization-based tissue birefringence mapping, and molecular imaging using intrinsic and nanoparticle-based contrast media are undergoing rapid development. Recent technology advances have also enabled the design of OCT-based highly phase-stable interference microscopes capable of resolving nanometer-scale structures and motions in living cells in the optical far field with ms temporal resolution. These new capabilities are being used to probe cellular internal and external surfaces and their responses to chemical and mechanical stimuli. The lecture will review the operating principles of these technologies and provide an overview of selected applications.
Joseph A. Izatt, Ph.D.
Professor of Biomedical Engineering and Ophthalmology
Durham, North Carolina
Joseph A. Izatt is Professor of Biomedical Engineering and Ophthalmology, and Program Director for Biophotonics at the Fitzpatrick Institute for Photonics at Duke University in Durham, North Carolina (http://www.bme.duke.edu/faculty/izatt/index.php). He is also Chairman and Chief Technology Officer at Bioptigen, Inc., a North Carolina startup company commercializing optical coherence tomography technology. Dr. Izatt’s research interests include biomedical optics and spectroscopy, coherence-based optical imaging in scattering media, and novel instrumentation for minimally invasive medical diagnostics. Dr. Izatt is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), Society of Photo-Instrumentation Engineers (SPIE), and Optical Society of America (OSA). Dr. Izatt has authored or co-authored over 150 peer-reviewed articles, book chapters, and patents related to coherence imaging.