9 items

Two commonly used uveitis drugs perform similarly in NIH-funded clinical trial

September 10, 2019

Methotrexate and the more expensive mycophenolate mofetil performed similarly in a head-to-head clinical trial that compared the two drugs for treating noninfectious uveitis, an eye disease that accounts for up to 15% of blindness in the U. S.

Microglia, the Immune Cells of the Central Nervous System, Shown to Regulate Neuroinflammation

April 22, 2019

A research team at Massachusetts Eye and Ear has shown that microglia, the primary immune cells of the central nervous system—including the retina of the eye—serve as “gatekeepers,” or biosensors and facilitators, of neuroinflammation...

Promising treatment for disease that destroys eye tissue

October 9, 2018

Researchers at the University of North Texas Health Science Center have shown that the MDM2 inhibitor class of drugs can treat uveitis in mice.

Therapy applied directly inside the eye best for treating uveitic macular edema

September 27, 2018

Delivery of corticosteroids directly into the eye is more effective than injections adjacent to the eye, according to results from a comparative clinical trial of macular edema in patients with noninfectious uveitis.

NIH researchers unleash therapeutic potential of IL-35

October 17, 2017

NIH scientists have simplified manufacturing and dosing of a potential drug candidate for the autoimmune eye disease uveitis—a vision-threatening condition that accounts for about 15 percent of blindness in the U.S.

Systemic therapy outperforms intraocular implant for treating uveitis

May 7, 2017

Systemic therapy consisting of corticosteroids and immunosuppressants preserved vision of uveitis patients better – and had fewer adverse outcomes – than a long-lasting corticosteroid intraocular implant, according to a clinical trial funded by NEI.

In Uveitis, Bacteria in Gut May Instruct Immune Cells to Attack the Eye

August 18, 2015

The inflammatory eye disorder autoimmune uveitis occurs when a person’s immune system goes awry, attacking proteins in the eye.

Soothing cells, peaceful protein could hold promise for treating autoimmune uveitis

June 30, 2014

Researchers at the National Eye Institute (NEI) have found a unique cell type that, in tests on mice, can protect against uveitis—a group of inflammatory diseases that affect the eye and can cause vision loss.

Translational research through teamwork

January 8, 2014

Imagine you are building a house. You would need a team of specialists, including an architect, a general contractor, carpenters, an electrician, a plumber and many others.