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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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Retinal cross section with photoreceptors and nuclei stained

ALG6 acts as a modifier gene in the inherited genetic eye disease retinitis pigmentosa 59

Variant of ALG6 delays rod photoreceptor degradation but decreases cone health in people with RP59 retinitis pigmentosa, according to a new study from University of Alabama, Birmingham.

Researchers closing in on genetic treatments for hereditary lung disease, vision loss

Researchers who work with tiny drug carriers known as lipid nanoparticles have developed a new type of material capable of reaching the lungs and the eyes, an important step toward genetic therapy for hereditary conditions like inherited vision loss.
fMRI of dog brain showing bright activation in the visual cortex.

Using fMRI, new vision study finds promising model for restoring cone function

Researchers have found that in dogs, fMRI can detect brain responses to daylight vision for black and white information as well as color information, and identify the area of the visual cortex that responds to stimulation of a cone-rich retinal region.

Putting regenerative therapies on the map

Members of the National Eye Institute's Audacious Goals Initiative (AGI) published an outline of milestones to reach before commencing clinical trials of regenerative therapies for retinal disease.

Stanford Medicine researchers build an eye ‘aging clock’ that could lead to treatments for ocular diseases

Using a technique they developed for studying eye fluid, Stanford Medicine researchers and their collaborators have found a way to measure ocular aging, opening avenues for treatment of numerous eye diseases.
Rhodopsin-bound nanobodies

UC Irvine researchers discover a nanobody which may lead to treatment for retinitis pigmentosa

University of California Irvine (UCI) researchers believe they have discovered a special antibody that may lead to a treatment for an inherited eye disease called retinitis pigmentosa.
Schematic showing SREDs bind to G-protein coupled receptors to promote cell survival

UCI researchers discover new drugs with potential for treating world’s leading causes of blindness

In a University of California, Irvine-led study, researchers have discovered small-molecule drugs with potential clinical utility in the treatment of age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP).
Rods and Cones image

Early study shows cones in retinal degeneration, thought to be dormant, may retain visual function

New UCLA research in mice suggests that “dormant” cone photoreceptors in the degenerating retina are not dormant at all, but continue to function, producing responses to light and driving retinal activity for vision.

Employee Offers Personal Account of NIH-Supported Clinical Research

Dr. David Kosub shares a first-hand experience of participating in the National Ophthalmic Disease Genotyping and Phenotyping Network (eyeGENE).
Multicolored image of photoreceptors and their long connecting processes, called axons, within a stem cell-derived retinal organoid

U. Wisconsin eye research uncovers how stem cell photoreceptors reach their targets

A new study reveals how photoreceptors grown from stem cells might extend biological wires, known as axons, to contact existing neurons.