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NAEC Meeting Minutes - June 14-15, 2001

Department Of Health And Human Services
National Institutes of Health
National Eye Institute

June 14-15, 2001

The National Advisory Eye Council (NAEC) convened for its ninety-eighth meeting at 8:30 a.m. on Thursday, June 14, 2001, in Conference Room G, Executive Plaza North, National Institutes of Health (NIH), Rockville, Maryland. The Acting Director of the National Eye Institute (NEI), Jack A. McLaughlin, Ph.D., presided as Chair of the Council. The meeting was open to the public on Thursday, June 14, 2001, from 8:30 a.m. until 4:15 p.m., followed by the closed session review of grant applications on Friday, June 15, 2001, from 8:30 a.m. until adjournment at 11:30 p.m. Attachment A provides a roster of Council members.

Council members present:

Dr. Dean Bok
Dr. Constance Cepko
Ms. Patricia A. Cleary
Dr. Martha C. Constantine-Paton
Lt. Col. William J. Flynn (Ex Officio)
Dr. M. Rosario Hernandez
Dr. Gordon E. Legge
Dr. Mildred M. G. Olivier
Mr. Richard J. Salem
Dr. P.Sarita Soni
Dr. J. Wayne Streilein
Dr. Larry J. Takemoto
Dr. Karla Zadnik
Dr. Marco A. Zarbin (Ex Officio)

NEI staff present:

Ms. Louise M. Amburgey
Ms. Margie Baritz
Ms. Diane Z. Baxter
Ms. Kym Collins-Lee
Dr. Mary Frances Cotch
Mr. William W. Darby
Mr. Michael Davis
Ms. Lois M. DeNinno
Ms. Linda Dingle
Dr. Peter A. Dudley
Ms. Lois Eggers
Mr. Donald F. Everett
Dr. Richard S. Fisher
Ms. Carol Fivozinsky
Dr. Ralph J. Helmsen
Dr. Richard Hertle
Ms. Jean Horrigan
Dr. Jeanette Hosseini
Dr. Chyren Hunter
Dr. Natalie Kurinij
Ms. Joan Lee
Dr. Ellen S. Liberman
Ms. Michele D. Lyles
Dr. Andrew P. Mariani
Dr. Jack A. McLaughlin
Dr. Loré Anne McNicol
Dr. Richard L. Mowery
Ms. Kathleen Moy
Ms. Angelia G. Neal
Dr. Michael D. Oberdorfer
Dr. Samuel C. Rawlings
Dr. John P. SanGiovanni
Ms. Karen Silver
Ms. Karen Robinson Smith
Dr. Janine Smith
Ms. Judy Stein
Ms. Marie E. Watkins
Mr. John Whitaker

Other National Institutes of Health (NIH) staff present:

Dr. Ronald Abeles, OBSSR
Dr. Michael Chaitin, CSR
Dr. Mary Custer, CSR
Joseph Januszewski, CIT
Dr. Raynard S. Kington, OBSSR
Dr. Carole L. Jelsema, CSR
Dr. Christine Melchior, CSR
Dr. Maryann Redford, NIDCR

Members of the general public present at the open session:

Mr. Michael Crissman, Association for Research in Vision and Ophthalmology
Mr. J. W. Dunlap, JtxRanches
Mr. Sean Jenkins, The Blue Sheet
Ms. Carrie Kovar, American Academy of Ophthalmology
Mr. Edward McManus, National Alliance for Vision Research
Ms. Lois Schoenbrun, American Academy of Optometry
Dr. Paul A. Sieving, University of Michigan
Dr. Santa Tumminia, Foundation Fighting Blindness
Dr. John Whitener, American Optometric Association


I. Call to Order and Opening Remarks

Dr. Jack A. McLaughlin, Acting Director, NEI, and Chair of the Council, called the meeting to order and welcomed the Council members and guests. Dr. McLaughlin introduced, Dr. Paul A. Sieving, the director-designate of the National Eye Institute. Dr. Sieving will officially join the NEI on June 17, 2001.

II. NIH Office of Behavioral and Social Sciences Research

Dr. McNicol, Director, Division of Extramural Research (DER) and Executive Secretary of the Council introduced Dr. Raynard S. Kington, Associate Director of the NIH for Behavioral and Social Sciences Research. Dr. Kington received his MD from the University of Michigan and did a residency in Internal Medicine at the Michael Reese Medical Center in Chicago. He was selected as a Robert Wood Johnson Clinical Scholar at the University of Pennsylvania and received both an MBA and PhD in the field of Health Policy and Economics. Before joining the NIH, Dr. Kington was Co-Director of the Drew/RAND Center on Health and Aging, a Senior Scientist in the Health Program at RAND, and Director of the Division of Health Examination Statistics at the National Center for Health Statistics of the CDC, where he was director of the NHANES survey.

Dr. Kington described the mission of the Office of Behavioral and Social Sciences Research (OBSSR), which is to strengthen and develop research on the social and cultural aspects of health. He indicated that the Office collaborates with NIH Institutes and Centers (ICs) to develop crosscutting initiatives and to collaborate on the design and implementation of a trans-NIH research agenda. Dr. Kington informed the Council of a strategic plan developed by the Committee on Future Directions for Behavioral and Social Sciences Research at the National Institutes of Health. Dr. Kington shared the executive summary of this document, “New Horizons in Health, An Integrative Approach” and stressed the priority areas of positive health promotion, health disparities research, and the social factors and behavioral factors, which affect disease. He indicated that the OBSSR looks forward to working with the NEI to set priorities for behavioral and social sciences research and to assist with the integration of appropriate biobehavioral perspectives for vision research. Council members indicated that they endorse this collaborative approach to strengthen research on the role that behavioral and social factors play in the function and health of the visual system.

III. Announcements and Introductions

Dr. McNicol announced several NEI staff changes. Dr. Mary Frances Cotch has left the DER to take a position as Chief, Epidemiology Branch in the NEI Division of Epidemiology and Clinical Research. Dr. Richard L. Mowery has left DER to assume the position of Special Assistant for Collaborative Clinical Research and Bioethics, Office of the Director, NEI.

Dr. Andrew P. Mariani is the new Director of the Fundamental Retinal Processes Program. Dr. Mariani received his Ph.D. from the Pennsylvania State University School of Medicine in retinal neuroanatomy. Following postdoctoral work in retinal physiology as a Staff Fellow in the Laboratory of Vision Research, NEI, and as a Senior Staff Fellow in the Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, he joined the NIH Division of Research Grants (DRG) as Scientific Review Administrator for the Neurological Sciences Study Section Subcommittee 1. In 1993 he returned to the NEI as Chief of the Scientific Review Branch.

Dr. Samuel C. Rawlings has been appointed Chief of the Scientific Review Branch. He received his Ph.D. in Physiological Psychology from the University of Miami. After postdoctoral work on binocular vision at the Bascom Palmer Eye Institute at the University of Miami, Dr. Rawlings became an Assistant Professor at the University of Houston College of Optometry, pursuing studies on electro-diagnostics. Dr. Rawlings then joined the NEI as an extramural program director before returning to academe as Director of Research in the Department of Ophthalmology at the University of Texas Health Science Center in San Antonio. In 1980 he returned to research administration in DRG as Executive Secretary of the Human Development and Aging Study Section. Dr. Rawlings was subsequently promoted to positions as Chief of the DRG Behavioral and Neurosciences Review Section and as Evaluation Officer for the Center for Scientific Review (CSR).

Ms. Louise M. Amburgey has joined the NEI Grants Management Branch as a grants management specialist. Ms. Amburgey received her Bachelor of Arts degree from the Western Maryland College. She then joined the National Center for Research Resources as a Grants Management Specialist, managing a portfolio of grants, which included the Biotechnology Resource Centers and the Regional Primate Research Centers. Ms. Amburgey next worked for the University of Missouri-Columbia, managing their clinical trials research portfolio. Dr. McNicol said that the NEI is pleased to have someone with Ms Amburgey’s broad experience in both government and university.

Dr. McNicol told the Council that the CSR recently announced the retirement of Dr. Leonard F. Jakubczak, the long-term Scientific Review Administrator for the Visual Sciences B study section. Dr. Jakubczak was a valued colleague in the visual neurosciences community.

IV. Confidentiality / Avoidance of Conflict of Interest

Dr. McNicol reviewed policies and procedures regarding confidentiality and avoidance of conflict of interest situations. To avoid conflict of interest, members of federal advisory committees must not participate in the discussion of any application or proposal in which they, their spouse, minor child, close professional associate, or organization has a financial interest or affiliation. The Council members signed a statement certifying that they were absent during such discussions.

V. Consideration of Minutes of Previous Meeting

The minutes of the February 8, 2001, NAEC meeting were approved as submitted.

VI. Future Council Meeting Dates

The following dates were agreed upon for future Council meetings:

September 13-14, 2001
February 14-15, 2002
June 13-14, 2002
September 12-13, 2002

Staff expects to need only a one-day meeting this fall on September 13, 2001.

VII. Budget Overview

Ms. Carol Fivozinsky, Budget Officer, NEI, presented an overview of the FY2002 NEI and NIH budgets. The President’s Budget calls for a 4% increase in overall federal government discretionary spending, but provides for a $2.75 billion (13.5%) increase in the NIH budget. Within this request, the NEI would receive a $60.5 million (11.8%) increase over FY2001, marking the third year of double digit percentage increases. However, the NEI is falling behind the goal of achieving a doubling of the budget over a five-year period. The President’s budget request includes several proposals regarding the NIH: multiyear funding authority to reduce out year commitments; a decrease in the salary cap for extramural investigators, an increase in the Program Evaluation tap, and new program initiatives in construction, bioterrorism research, bioengineering, clinical loan repayment programs, and lung cancer prevention in women.

The proposed NEI appropriation would be distributed among extramural grants and research and development contracts ($504 million), the Division of Intramural Research ($51 million) and Research Management and Support ($16 million). The FY2002 extramural funds would include $475 million for research grants, $10.7 million for research training, and $18 million for research and development contracts.

Mr. Edward McManus, Executive Director of the National Alliance for Eye and Vision Research (NAEVR), described the citizen’s Professional Judgment Budget request for the NEI. For FY2002 it calls for a budget of $620 million, a 21% increase over the FY 2001 level. Mr. McManus reviewed other NAEVR activities. These included a Capital Hill reception honoring Dr. Carl Kupfer, “Celebrating 30 Years of Progress in Eye and Vision Research”; preparation of a brochure highlighting the accomplishments of the NEI, entitled “Saving Sight: Celebrating Achievements in Eye and Vision Research”; a successful public letter writing campaign to members of the House of Representatives and the Senate supporting increased funding of the NEI; and a Congressional educational briefing with the Foundation Fighting Blindness entitled “National Eye Institute-supported Research Holds Hope for Children Born Blind and Their Families”.

VIII. Extramural Budget Trends

Dr. McNicol reviewed historical budget trends for the extramural research program and noted that the FY2001 budget of $510 million represents a 13.4% increase over the FY2000 level. This is the third year of double digit increases. The NEI anticipates funding approximately 1106 research project grants, 38 more than in FY2000. The annual total cost of these grants will increase by 19%, leading to a slight drop in the award rate to 39%. Funding levels for other grant mechanisms will also increase. NEI anticipates increasing the investment in Small Business Innovative Research (R43 and R44) and Small Business Technology Transfer Research (R41 and R42) grants by 10%; Center Core Grant (P30) funding by 23%, cooperative clinical research by 11%, and research training by 8%.

IX. National Institute of Biomedical Imaging and Bioengineering

Dr. McNicol gave an overview of the status of the new National Institute of Biomedical Imaging and Bioengineering (NIBIB). Established by H.R. 1795 and enacted on December 29, 2000, NIBIB’s mission is to improve health by promoting fundamental discoveries, design and development, and translation and assessment of technological capabilities. In support of its mission, NIBIB will partner with NIH ICs to translate fundamental discoveries into research and applications for specific diseases, disorders, or biological processes. Current efforts are aimed at developing the Institute and transitioning appropriate imaging and bioengineering activities into the NIBIB. The NEI, along with other IC program staffs are identifying non-competing grants to be transferred to NIBIB along with funds for FY2002 and out years.

X. NEI Small Grants for Pilot Research (R03) Program Update

Dr. Richard S. Fisher, Director, Corneal Diseases Program, described the initial response to this new NEI grant initiative. There was an enthusiastic response from the vision research community. Eighty-seven applications were reviewed by an NEI Special Emphasis Panel for consideration at the June 2001, Council meeting. The applications covered the full range of NEI programmatic interests and were evaluated on the basis of scientific and technical merit criteria, which included an emphasis on the conceptual framework and general approach to the problem, with less emphasis on methodological details and preliminary data.

XI. NEI Support for DNA Microarray Facilities

Dr. Ellen S. Liberman, Director, Lens and Cataract and Glaucoma Programs, described the results of the second NEI solicitation for administrative supplements to support DNA microarray facilities. NEI was able to fund nine supplements in FY2001, at a total cost of $1,984,736. Overall, the DNA microarray facilities initiative has provided funding to 19 institutions.

XII. NEI Workshop on Craniofacial Muscle Specialization and Neurodegeneration

Dr. Chyren Hunter, Director, Oculomotor Systems Program, described the workshop, “Craniofacial Muscle Specialization and Neurodegeneration”, which was held at the NIH on March 7-8, 2001. This workshop was sponsored by the NEI in collaboration with the NIH Office of Rare Diseases. There has been considerable recent scientific progress in this field identifying regulatory factors for muscle development, developing novel techniques for non-invasive imaging of muscle, and proposing novel hypotheses for the molecular mechanisms of eye movement.

The workshop focused particularly on the unique aspects of extraocular, laryngeal, and temporomandibular muscle that make them selectively vulnerable or resistant to disease. The speakers and discussants contributed a wide range of perspective to assist in the formulation of new research opportunities for the NEI. The workshop recommendations included suggestions that the NEI establish extraocular muscle tissue banks, support the addition of the serially-sectioned globe to the Virtual Human Project, and highlight extraocular muscle gene expression data on the NEIBank vision research web site. Council supported continuing efforts to stimulate this area of research.

XIII. FY2002 Instrumentation Initiative

Dr. Liberman outlined a possible funding initiative for FY2002 that would provide administrative supplements for technology enhancement. The purpose of this initiative would be to develop and expand technological capabilities that will enhance ongoing vision research by introducing innovative technologies and/or upgrading existing facilities. Examples of such technology could include proteomics, high throughput in situ hybridization, protein sequencing capabilities, transgenic animal facilities, confocal microscopy, DNA microarray facilities, and computer hardware and software for bioinformatics analysis. The initiative is envisioned as providing one-time administrative supplements to meet instrumentation needs identified and justified by small groups of NEI-funded investigators.

Council members enthusiastically endorsed the general concept for this initiative. They remarked that centralized facilities for transgenic animals and in situ hybridization analyses would be particularly valuable to the field at this time.

XIV. Orientation to Updated Release of the NIH Electronic Council Book

Dr. McNicol introduced Dr. Thorsten Fjellstedt, Deputy Director, Office of Program Operations, National Institute for Environmental Health Sciences. Dr. Fjellstedt played a leading role in the development of both the staff and the council member versions of the Electronic Council Book (ECB). This past year he has been on a part time detail to the NIH Office of Extramural Research, Office of the Director, NIH, in order to implement the current ECB upgrades in response to council member feedback.

Dr. Fjellstedt presented a “walk-through” of the new system, which will be introduced for use in the October 2001, Council review round. New features will include lengthening session time before automatic log out, ability to select summary statements released since a member’s last search session, summary statement text search capability, rapid downloading of multiple summary statements into both Zip files and pdf files, improved summary statement printing options which include better formatting options, and more facile control of search string inclusion/exclusion criteria.

XV. FY2002 Initiatives on the Genetics of Diabetic Retinopathy

Dr. Peter A. Dudley, Director, Retinal Diseases Program, described the progress that has been made implementing the recommendations of the September 2000, NEI-supported workshop on the genetics of diabetic retinopathy. The workshop participants had identified a set of nine collaborations and/or research studies to be developed and these recommendations were published on the NEI website. Dr. Dudley summarized implementation activities: 1. The workshop co-chairs are collaborating on a review article, which discusses and outlines existing information on heritable factors for diabetic retinopathy; 2. A working group met at the Association for Research in Vision and Ophthalmology annual meeting in May, 2001, to discuss issues regarding the development and distribution of animal models; 3. Genomic information will be made available through the NEIBank vision research website; 4. NEI has joined with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in preparing a trans-NIH Request for Applications (RFA) soliciting applications to develop surrogate markers for diabetic complications. This RFA will be supported in FY2002 through the Type I diabetes special fund; 5. The NEI is supplementing the Family Investigation of Nephropathy and Diabetes Study in order to include a component to identify genes responsible for diabetic retinopathy and their linkage relationships to other diabetic complications; and 6. The NEI is developing a Program Announcement for FY2002 to encourage research on the genetic predisposition underlying the development and progression of diabetic retinopathy. Council members endorsed these implementation efforts and encouraged staff to develop the proposed initiatives.

XVI. NEI Workshop on Classification of Eye Movement Abnormalities and Strabismus

Dr. Richard W. Hertle, a clinician scientist in the NEI Laboratory of Sensorimotor Research, outlined the outcome of an NEI-sponsored “Workshop on Classification of Eye Movement Abnormalities and Strabismus” (CEMAS), held in Bethesda, MD on February 9-10, 2001. The field of strabismus and eye movements has seen an explosion in scientific investigation and clinical expertise in recent years. Although there are numerous published classification systems for these disorders, none crosses scientific disciplines or cultural boundaries. This lack of uniformity precludes cooperative efforts among the various scientific disciplines involved with the care of these patients (these fields include ophthalmology, optometry, behavioral psychology, psychiatry, neurology, otolaryngology, neurobiology, visual psychophysics, bioengineering, and mathematics). And the lack of uniformity makes collaborative multicenter longitudinal studies and/or clinical trials almost impossible.

In 1998, NEI intramural researchers organized a small working group, including seven extramural experts, which prepared a formal planning document and agenda for the CEMAS workshop. An international group of 22 scientists and clinicians from varied disciplines was invited and charged with developing a clinically pragmatic, uniform classification. The classification was to provide a foundation with the potential for change and grown, with definitions that could be used as inclusion/exclusion criteria for clinical trials. The group produced a document, which organizes over 115 disease entities into a specific, non-eponymic nomenclature of eight major groups. This manuscript has been sent for comment prior to submission for full publication as a stand-alone addendum to a monthly ophthalmology journal. The full text will be published on the NEI web site as an HTML/PDF document in outline form with hyperlinks to the description boxes for each disease. Over the next two to six years, it is hoped that this classification system can be incorporated in the American Academy of Ophthalmology home study course manuals.

Council members strongly endorsed continued NEI efforts to support the publication and distribution of the CEMAS document.

XVII. Discussion of NEI Activiites in Health Disparities Research: Recruitment of Minority Investigators and Patients


Dr. McNicol reviewed NIH strategic goals for reducing and eliminating differences in the incidence, prevalence, mortality, and burden of adverse health conditions in US minority populations. She highlighted major vision disorders that show marked health disparities (such as dry eye syndrome, glaucoma, myopia, diabetic retinopathy, and aging related macular degeneration) and stressed the role of council oversight in providing additional opportunities to address rare diseases, such as hereditary benign intraepithelial dysketatosis, which markedly effect particular minority groups.

Research supplements for underrepresented minorities

Dr. McNicol described NEI participation in this trans-NIH program, which is detailed at http://grants.nih.gov/grants/guide/pa-files/PA-01-079.html She stressed the strengths of this initiative, which include flexibility; ease of application; placement of minority individuals in strong research environments; incentives for mentors to recruit and support talented minority individuals; and support for individuals at all stages of training, from high school students to faculty and staff.

Training programs in minority-serving institutions

Dr. Chyren Hunter, Training Officer, described NEI participation with ten other Institutes in supporting an initiative for Clinical Research Training in Minority Institutions (CRTMI), co-sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Center for Minority Health and Health Disparities (NCMHHD). The CRTMI is designed to initiate didactic programs in clinical research and to support and expand existing programs in clinical research in minority institutions. For FY2001 the initiative will award $1.2 million to support one-year Phase I R21 planning grants at six institutions. For FY2002, Phase II U25 grant applications will be funded. Each Phase II award is estimated to cost $540,000 per year, for five years. They will support the development and implementation of curriculum-dependent programs in minority institutions to train selected doctoral and postdoctoral candidates in clinical research leading to a Master of Science in Clinical Research or Master of Public Health in a clinically relevant area. It is anticipated that successful programs will produce well-trained clinical researchers who can lead clinical research projects.

Minority recruitment in NEI phase III clinical trials and collaborative clinical research

Dr. Natalie Kurinij, Group Leader, Epidemiology and Clinical Studies, reviewed NIH policy. Women and members of minority groups and their subpopulations must be included in clinical trials unless a clear and compelling rationale and justification establishes that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. Cost is not an acceptable reason for exclusion except when the study would duplicate data from other sources. Study design must permit valid analyses to detect significant differences in intervention effect. NEI staff actively collaborates with clinical study leadership in the development and analysis of appropriate protocols, and actively monitors recruitment at all stages.

NEI collaboration with the National Medical Association

Council member Dr. Mildred M. G. Olivier, Midwest Glaucoma Center, described minority outreach opportunities provided by the National Medical Association (NMA). Established in 1895, the NMA is the oldest national organization representing African American physicians and health professionals in the United States. Its mission is to be the nation’s voice for parity and justice in medicine and the elimination of disparities in health. NMA Ophthalmology supports a postgraduate symposium recognizing resident’s research, presents and coordinates physician scientist training awards to minority physicians, works with the Medical Schools Council of Deans to identify and support students interested in careers in vision research, and works with the NEI to highlight research support opportunities.

Dr. Dudley described his interactions with NMA Ophthalmology. He regularly attends annual meetings to provide updated information regarding NEI programs, answer questions, and learn of important issues or areas of concern.

Trans-NIH collaborations

Dr. McNicol described initiatives where other NIH ICs co-fund vision research on health disparities. In FY2000, the NCMHHD provided $1.15 million to recruit additional minority sub-populations to ongoing NEI-sponsored clinical trials, and the NIDDK provided $2.17 million to co-fund the UK Prospective Diabetes Study and support six R21 developmental grants to study the pathogenesis of diabetic retinopathy.

NEI participates in another collaborative activity in this area by providing the NIH Office of Extramural Research with copies of our booklet, “Opportunities for Underrepresented Minority Medical Students” for distribution at national scientific meetings at the NIH exhibit booth.

Minority Biomedical Research Support program

Dr. Ralph J. Helmsen, Research Resources Officer, described NEI collaborations with the National Institute for General Medical Sciences through the Minority Biomedical Research Support (MBRS) program. MBRS provides awards through the S06 mechanism to educational institutions with substantial minority enrollments to support research by faculty members; strengthen the institutions’ biomedical research capabilities; and increase the interest, skills, and competitiveness of students and faculty in pursuit of biomedical research careers. In FY2001, the NEI will provide $385,745 for competitive S06 awards in vision research.

NEI Office of Communication, Health Education, and Public Liaison activities for minority outreach

Ms. Judith Stein, Associate Director for Health Education and Communication, described the minority outreach activities of her office. When minority populations are the targets for NEI communications activities, materials are developed and pre-tested with that audience in order to provide the most efficient channels of communication. Current activities include maintenance of the NEI website with its clinical studies database; dissemination of research results; response to public inquiries; production and dissemination of publications; administration of the Diabetic Eye Disease, Glaucoma Education, and Low Vision Education Programs; preparation of traveling exhibits; implementation of the VISION School Program; and coordination of the VISION Public Information Network.

XVI. Review of Research and Training Applications

The Council considered 309 research and training applications requesting $415.5 million in total all year costs. The Council recommended 268 applications with a total all year cost of $370.1 million. Council members absented themselves from the meeting during discussion of and voting on applications from their own institutions, or other applications in which there was a potential conflict of interest, real or apparent. Members signed a statement to this effect.

Closed Portion of the Meeting

The next portion of the meeting was closed to the public in accordance with the determination that it was concerned with matters exempt from mandatory disclosure under Sections 552b(c)(4) and 552b(c)(6), Title 5, U.S. Code and Section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2).

XVIII. Review of Research and Training Applications

The Council considered 387 research and training applications requesting $409.0 million in total all year costs. The Council recommended 368 applications with a total all year cost of $388.4 million. Council members absented themselves from the meeting during discussion of and voting on applications from their own institutions, or other applications in which there was a potential conflict of interest, real or apparent. Members signed a statement to this effect.

XVIX. Adjournment

Dr. McLaughlin adjourned the meeting at 11:30 am on June 15, 2001.

XX. Certification

I hereby certify that, to the best of my knowledge, the foregoing minutes and attachment(s) are accurate and complete.

# # #

Loré Anne McNicol, Ph.D.
Executive Secretary
National Advisory Eye Council
Director, Division of Extramural Research
National Eye Institute

Jack A. McLaughlin, Ph.D.
National Advisory Eye Council
Acting Director
National Eye Institute

These minutes will be submitted for the approval of the Council at the September 13, 2001, meeting. Any corrections or notations will be incorporated into the minutes of that meeting. A complete, printed copy of the Council minutes, including attachments, may be obtained from:

Ms. Marie E. Watkins
National Eye Institute
Executive Plaza South, Suite 350
6120 Executive Blvd MSC 7164
Bethesda, MD 20892-7164
Telephone: (301) 496-5561
FAX: (301) 402-0528
e-mail: mev@nei.nih.gov

# # #

Attachment A

National Advisory Eye Council
National Eye Institute

(Terms end 11/30 of the designated year)

Dean Bok, Ph.D. (02)
Professor of Neurobiology and Ophthalmology
University of California, Los Angeles
Los Angeles, CA 90095-1763

Constance Cepko, Ph.D. (01)
Professor of Genetics
Harvard Medical School
Boston, MA 02115

Patricia A. Cleary, M.S. (02)
Senior Research Staff Scientist
The George Washington University
Rockville, MD 20852

Martha C. Constantine-Paton, Ph.D. (03)
Professor of Biology
Massachusetts Institute of Technology
Cambridge, MA 02139

M. Rosario Hernandez, D.D.S. (02)
Associate Professor of Ophthalmology and Visual Sciences
Washington University
St. Louis, MO 63110

Gordon E. Legge, Ph.D. (03)
McKnight Distinguished University Professor of Psychology
University of Minnesota Twin Cities
Minneapolis, MN 55455-0344

Mildred M. G. Olivier, M.D. (04)
President and CEO
Midwest Glaucoma Center, P.C.
Hoffman Estates, IL 60194

Richard J. Salem, J.D. (01)
Senior Partner
Salem, Saxon, and Nielsen, P.A.
Tampa, FL 33602

P. Sarita Soni, O.D. (03)
Professor of Optometry & Visual Science
Indiana University
Bloomington, IN 47405

J. Wayne Streilein, M.D. (04)
President and Director of Research
Schepens Eye Research Institute
20 Staniford ST
Boston, MA 02114

Larry J. Takemoto, Ph.D. (02)
Professor of Biology
Kansas State University
Manhattan, KS 66506

Karla Zadnik, O.D., Ph.D. (04)
College of Optometry
Ohio State University
Columbus OH 43210-1240

Department of Defense Representative

Lt. Col. William J. Flynn, USAF, MC, M.D.
Department of Ophthalmology
Wilford Hall Medical Center
Lackland Air Force Base, TX 78236

Department of Veterans Affairs Representative

Marco Z. Zarbin, M.D., Ph.D.
New Jersey Veterans Admin. Hospital
Newark, NJ 07103

Ex Officio Members

Tommy G. Thompson
Department of Health & Human Services
Washington, DC 20201

Ruth L. Kirschstein, M.D.
Principal Deputy Director
National Institutes of Health
Bethesda, MD 20892


Jack A. McLaughlin, Ph.D.
Acting Director
National Eye Institute
National Institutes of Health
Bethesda MD 20892

Executive Secretary

Loré Anne McNicol, Ph.D.
Division of Extramural Research
National Eye Institute
National Institutes of Health
Bethesda, MD 20892