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Immunopathology Section

Recent Publications

Selected Review Articles

C.C. Chan, Q. Li: Immunopathology of uveitis. Br J Ophthalmol 82:91-96, 1998. PubMed

G. Adamus, C.C. Chan: Experimental autoimmune uveitides: Multiple antigens, diverse diseases. In Caspi, R.R. (ed.): The eye: Immunity and autoimmunity. Int Rev Immunol 21:209-229, 2002. PubMed

C.C. Chan: Molecular pathology of primary intraocular lymphoma. Tranas Am Ophthalmol Soc 101:275-292, 2003. PubMed

J. Tuo, C.M. Bojanowski, C.C. Chan: Genetic factors of age-related macular degeneration. Prog Ret Eye Res 23:229-249, 2004. PubMed

C.C. Chan, J.A. Gonzales: Primary Intraocular Lymphoma. World Scientific Publishing Co., Singapore, London, Hackensack NJ, 2007. World Scientific

M. Patel, C.C. Chan: Immunopathological aspects of age-related macular degeneration. Sem Immunopathol 30:97-110, 2008. PubMed

X. Ding, X. Ding, M. Patel, C.C. Chan: Molecular pathology of age-related macular degeneration. Prog Ret Eye Res 28:1-18, 2009. PubMed

H.L. Ramkumar, J. Zhang, C.C. Chan: Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Ret Eye Res 29:169-190, 2010. PubMed

Y. Wang, V.M. Wang, C.C. Chan: The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment. Eye 25:127-139, 2011. PubMed

C.C. Chan, J.L. Rubenstwin, S.E. Coupland, J.L. Davis, J.W. Harbour, P.B. Johnston, N. Cassoux, V. Touitou, J.R. Smith, T.T. Batchelor, J.S. Pulido: Primary vitreoretinal lymphoma: A report from an international primary central nervous system lymphoma collaborative group symposium. The Oncologist 16:1589-1599, 2011. PubMed

D. Ardeljan, C.C. Chan: Aging is not a disease: Distinguishing age-related macular degeneration from aging. Prog Ret Eye Res 37:68-89, 2013. PubMed

Peer Reviewed Journal Articles (Recent Three Years)

M.M. Liu, J. Tuo, C.C. Chan: Gene therapy for ocular diseases. Br J Ophthalmol 95:604-612, 2011. PubMed

C.C. Chan, M.M. Liu, J.C. Tsai: The first Western style hospital in China. Arch Ophthalmol 129:791-797, 2011. PubMed

Y. Cho, X. Cao, D. Shen, J. Tuo, L.M. Parver, F.R. Rickles, C.C. Chan: Evidence for enhanced tissue factor expression in age-related macular degeneration. Lab Invest 91:591-526, 2011. PubMed

M.M. Liu, E. Furusato, X. Cao, D. Shen, C.C. Chan: Ocular manifestations and pathology of adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type 1 (HTLV-1). Rare Tumors 2:e63;179-182, 2010. PubMed

D. Shen, X. Cao, L. Zhao, J. Tuo, W.T. Wong, C.C. Chan: Naloxone ameliorates retinal lesions in Ccl2/Cx3cr1 double deficient mice via modulation of microglia. Invest Ophthalmol Vis Sci 52:2897-2904, 2011. PubMed

E. Furusato, D. Shen, X. Cao, B. Furusato, R.B. Nussenblatt, E.J. Rushing, C.C. Chan: Inflammatory cytokine and chemokine expression in sympathetic ophthalmia. Histol Histopathol 26:1145-1151, 2011. PubMed

M.M. Liu, E. Agron, E.Y. Chew, C.B. Melerle, F.L. Ferris, III, C.C. Chan, J. Tuo: Copy number variation in candidate genes in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 52:3129-3135, 2011. PubMed

J. Tuo, J.J. Pang, X. Cao, D. Shen, J. Zhang, A. Scaria, S.C. Wadsworth, P. Pechan, S.L. Boye, W.W. Hauswirth, C.C. Chan: AAV-5 mediated sFLT01 gene therapy arrests retinal lesions in Ccl2-/-/Cx3cr1-/- mice. Neurobiol Aging 33:433.e431-433.e410, 2011. PubMed

H.L. Ramkumar, B.P. Brooks, X. Cao, D. Tamura, J.J. DiGiovanna, K.H. Kraemer, C.C. Chan: Ophthalmic manifestations and histopathology of xeroderma pigmentosum: Two clinicopathological cases and review of the literature. Surv Ophthalmol 56:348-361, 2011. PubMed

D.N. Hu, M. Chen, D.Y. Zhang, F. Ye, S.A. McCormick, C.C. Chan: Interleukin-1β increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via p38 MAPK/NF-κB pathway. Invest Ophthalmol Vis Sci 52:3767-3774, 2011. PubMed

X. Cao, R. Ursea, D. Shen, H.L. Ramkumar, C.C. Chan: Hypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring: a case report. J Med Case Rep 5:398, 2011. PubMed

X. Cao, D. Shen, M.M. Patel, J. Tuo, T.M. Johnson, T.W. Olsen, C.C. Chan: Macrophage polarization in the maculae of age-related macular degeneration: a pilot study. Pathol Int 61:528-535, 2011. PubMed

F. Forooghian, A.B. Merkur, V. White, D. Shen, C.C. Chan: High-definition optical coherence tomography features of primary vitreoretinal lymphoma. Ophthal Surg Las Im 42:e97-99, 2011. PubMed

D. Ardeljan, J. Tuo, C.C. Chan: Carboxyethylpyrrole plasma biomarkers in age-related macular degeneration. Drug Future 36:713-718, 2011. PubMed

Y. Wang, D. Shen, V.M. Wang, H.N. Sen, C.C. Chan: Molecular biomarkers for the diagnosis of primary vitreoretinal lymphoma. Int J Mol Sci 12:5684-5697, 2011. PubMed

C.C. Chan, J.L. Rubenstwin, S.E. Coupland, J.L. Davis, J.W. Harbour, P.B. Johnston, N. Cassoux, V. Touitou, J.R. Smith, T.T. Batchelor, J.S. Pulido: Primary vitreoretinal lymphoma: A report from an international primary central nervous system lymphoma collaborative group symposium. The Oncologist 16:1589-1599, 2011. PubMed

J. Tuo, S. Grob, K. Zhang, C.C. Chan: Genetics of immunological and inflammatory components in age-related macular degeneration. Ocul Immunol Inflamm 20:27-36, 2012. PubMed

J. Tuo, X. Cao, D. Shen, Y. Wang, J. Zhang, J.Y. Oh, D.J. Prockop, C.C. Chan: Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model. J Neuroinflamm 9:59, 2012. PubMed

S. Park, C.C. Chan: Von Hippel-Lindau disease (VHL): A need for a murine model with retinal hemangioblastoma. Histol Histopathol 27:975-984, 2012. PubMed

M.E. Aronow, G. Adamus, M. Abu-Asab, Y. Wang, C.C. Chan, A.D. Singh: Paraneoplastic vitelliform retinopathy: Clinicopathologic correlation and review of the literature. Surv Ophthalmol 57:558-564, 2012. PubMed

M.J. Mattapalli, E.F. Wawrousek, C.C. Chan, H. Zhao, J. Roychoudhury, T.A. Ferguson, R.R. Caspi: The rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 53:2921-2927, 2012. PubMed

H.L. Ramkumar, D.F. Shen, J. Tuo, R.M. Braziel, S.E. Coupland, J.R. Smith, C.C. Chan: IL-10 -1082 SNP and IL-10 in primary CNS and vitreoretinal lymphoma. Graefe's Arch Clin Exp Ophthalmol 250:1541-1548, 2012. PubMed

N. Nagarkatti-Gude, Y. Wang, M.J. Ali, S.G. Honavar, M.J. Jager, C.C. Chan: Genetics of primary intraocular tumors. Ocul Immunol Inflamm 20:244-254, 2012. PubMed

B. Liu, C.C. Chan, R.B. Nussenblatt: Application of Small Molecules/Macromolecules in Ocular Inflammatory Diseases. Anti-inflamm Anti-allergy Agents Med Chem 11:113-120, 2012. PubMed

Y. Wang, D. Shen, V.M. Wang, C.R. Yu, R.X. Wang, J. Tuo, C.C. Chan: Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress. Apoptosis 17:1144-1155, 2012. PubMed

M.M. Liu, C.C. Chan, J. Tuo: Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics. Hum Genomics 6:13, 2012. PubMed

V.M. Wang, R.B. Rosen, C.B. Meyerle, S.K. Kurup, D. Ardeljan, E. Agron, K. Tai, M. Pomykala, E.Y. Chew, C.C. Chan, J. Tuo: Suggestive association between PLA2G12A SNP rs2285714 and response to anti-VEGF therapy in patients with exudative age-related macular degeneration. Mol Vis 18:2578-2585, 2012. PubMed

X.K. Chu, J. Tuo, C.C. Chan: Genetics of AMD: application to drug design. Future Med Chem 5:13-15, 2013. PubMed

Y. Wang, M.S. Abu-Asab, W. Li, M.E. Aronow, A.D. Singh, C.C. Chan: Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy. BMC Ophthalmol 12:56, 2012. PubMed

L. Wei, B. Liu, J. Tuo, D. Shen, P. Chen, Z. Li, X. Liu, J. Ni, P. Dagur, H.N. Sen, S. Jawad, D. Ling, S. Park, S. Chakrabarty, C. Meyerle, E. Agron, F.L. Ferris 3rd, E.Y. Chew, J.P. McCoy, E. Blum, P.J. Francis, M.L. Klein, R.H. Guymer, P.N. Baird, C.C. Chan, R.B. Nussenblatt: Hypomethylation of IL17RC promoter associates with age-related macular degeneration. Cell Report 2:1151-1158, 2012. PubMed

X.K. Chu, Y. Wang, D. Ardeljan, J. Tuo, C.C. Chan: Controversial view of a genetically altered mouse model of focal retinal degeneration. Bioengineered 4:130-135, 2012. PubMed

D. Ardeljan, C.B. Meyerle, E. Agron, J.J. Wang, P. Mitchell, E.Y. Chew, J. Zhao, A. Maminishkis, C.C. Chan, J. Tuo: Influence of TIM3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration. Eur J Hum Genet 21:1152-1157, 2013. PubMed

C.C. Chan, H.N. Sen: Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma. Discov Med 15:93-100, 2013. PubMed

J. Zhang, J. Tuo, X. Cao, D. Shen, W. Li, C.C. Chan: Early degeneration of photoreceptor synapse in Ccl2/Cx3cr1 deficient mice on Crb1rd8 background. Synapse 67:515-531, 2013. PubMed

H.L. Ramkumar, J. Tuo, D.F. Shen, J. Zhang, X. Cao, E.Y. Chew, C.C. Chan: Nutrient supplementation with n-3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1 deficient mice on Crb1rd8 background. J Nutr 143:1129-1135, 2013. PubMed

Y. Wang, B.E. Marciano, D. Shen, R.J. Bishop, S. Park, S.M. Holland, C.C. Chan: Molecular identification of bacterial DNA in the chorioretinal scars of chronic granulomatous disease. J Clin Immunol 33:917-924, 2013. PubMed

X.K. Chu, C.C. Chan: Sympathetic ophthalmia: to the 21st century and beyond. J Ophthalmic Inflamm Infect 3:49, 2013. Springer

M.D. Dalal, C.W. Morgans, R.M. Duvoisin, E.A. Gamboa, B. Jeffrey, S. Garg, C.C. Chan, H.N. Sen: Diagnosis of occult melanoma using TRPM1 autoantibody testing: A novel approach. Ophthalmology 120:2560-2564, 2013. PubMed

M.M. Liu, C.C. Chan, J. Tuo: Epigenetics in ocular diseases. Curr Genomics 14:166-172, 2013. PubMed

Supplemental Materials

C. Cukras, C.C. Chan: Chapter IV. Diagnosis and treatment of retinitis pigmentosa based on the pathology. In Retinitis Pigmentosa: Causes, diagnosis and treatment. Nova Science Publisher, Hauppauge, NY 2010; pp.111-125. Nova Science Pub

H.E. Wiley, C.C. Chan: Chapter 1. Correlation of phenotype and genotype in age-related macular degeneration. In Macular degeneration: Causes, Diagnosis and Treatment. E.J. Campbell, L.M. McMarnn (eds). Nova Science Publisher, Hauppauge, NY 2011; pp. 1-28. Nova Science Pub

T.A. Larson, H.N. Sen, C.C. Chan: Chapter VI. Clinical and immunological highlights of non-infectious uveitis. In Advances in Eye Research. Volume 1. Nova Science Publisher, Hauppauge, NY 2011; pp. 131-146. Nova Science Pub

V.M. Wang, J. Tuo, C.C. Chan: Chapter 3. Animal models to evaluate ocular nanoparticular drug delivery systems. In Ocular Drug Delivery: Barriers and Application of Nanoparticular Systems. D. Thassu, G. Chader (eds). Taylor & Francis, Oxford, UK. 2012; pp. 41-58. Taylor & Francis

C.C. Chan, W.M. Smith: Chapter 25. Inflammatory response and mediators in retinal injury. In Retina Fifth Edition. S.J. Ryan, A.P. Schachat, C.P. Wilkinson, D.R. Hintinm S. Sadda, P. Wiedemann (eds). Elsevier. London, UK. 2013; pp. 553-561. Elsevier

Last Reviewed: December 2013

Department of Health and Human Services NIH, the National Institutes of Health